Food protein–induced enterocolitis and alpha-1-antitrypsin deficiency

Singer, A

doi:10.1016/j.jaci.2019.09.027

Cited by 2 publications

(5 citation statements)

References 8 publications

(9 reference statements)

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“…Majamaa et al [48] observed that an increased concentration of fecal α1-antitrypsin is associated with CMA in infants with atopic eczema. However, other authors analyzed α 1-antitrypsin levels along with a panel of different markers in patients with GIT disorders and found no significant differences for this protein [32,49]. In relation to CMA, there are scarce data, and the results are contradictory.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the use of fecal biomarkers for the diagnosis of CMA has recently been reviewed [27]. The proteins most studied as potential fecal biomarkers of this disease are fecal calprotectin, α-1 antitrypsin, and lactoferrin [28][29][30][31][32]. α1-Antitrypsin is a nondietary serum protein synthesized in the liver [33].…”

Section: Introductionmentioning

confidence: 99%

“…α1-Antitrypsin is a nondietary serum protein synthesized in the liver [33]. It is resistant to digestive degradation and can therefore be reliably used to assess excessive gastrointestinal protein losses [32,34]. Lactoferrin is a globular protein belonging to the family of transferrin, non-heme ironbinding glycoproteins [35].…”

Section: Introductionmentioning

confidence: 99%

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Further Insights into the Gut Microbiota of Cow’s Milk Allergic Infants: Analysis of Microbial Functionality and Its Correlation with Three Fecal Biomarkers

Zubeldia‐Varela

Barker-Tejeda

Mera-Berriatua

et al. 2023

IJMS

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Cow’s milk allergy (CMA) is one of the most prevalent food allergies in children. Several studies have demonstrated that gut microbiota influences the acquisition of oral tolerance to food antigens at initial stages of life. Changes in the gut microbiota composition and/or functionality (i.e., dysbiosis) have been linked to inadequate immune system regulation and the emergence of pathologies. Moreover, omic sciences have become an essential tool for the analysis of the gut microbiota. On the other hand, the use of fecal biomarkers for the diagnosis of CMA has recently been reviewed, with fecal calprotectin, α-1 antitrypsin, and lactoferrin being the most relevant. This study aimed at evaluating functional changes in the gut microbiota in the feces of cow’s milk allergic infants (AI) compared to control infants (CI) by metagenomic shotgun sequencing and at correlating these findings with the levels of fecal biomarkers (α-1 antitrypsin, lactoferrin, and calprotectin) by an integrative approach. We have observed differences between AI and CI groups in terms of fecal protein levels and metagenomic analysis. Our findings suggest that AI have altered glycerophospholipid metabolism as well as higher levels of lactoferrin and calprotectin that could be explained by their allergic status.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Further Insights into the Gut Microbiota of Cow’s Milk Allergic Infants: Analysis of Microbial Functionality and Its Correlation with Three Fecal Biomarkers

Zubeldia‐Varela

Barker-Tejeda

Mera-Berriatua

et al. 2023

IJMS

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“…On the other hand, α-1 antitrypsin is an inhibitor of serine proteases present in serum which is synthesized in the liver [85]. It can be measured to assess the excessive GI protein losses in patients with protein-losing enteropathy (PLE) [86,87]. It should be noted that PLE must not be confused with α-1 antitrypsin deficiency, a separate condition, as has sometimes been reported in the literature [87].…”

Section: Fecal Biomarkers Protein Analysismentioning

confidence: 99%

“…It can be measured to assess the excessive GI protein losses in patients with protein-losing enteropathy (PLE) [86,87]. It should be noted that PLE must not be confused with α-1 antitrypsin deficiency, a separate condition, as has sometimes been reported in the literature [87]. In the case of CMA, there is very little data: to the best of our knowledge, only one paper reports its measurement in a study of CMA, alongside a panel of other markers, and did not find significant differences for this protein [88].…”

Section: Fecal Biomarkers Protein Analysismentioning

confidence: 99%

Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

Zubeldia‐Varela

Barker-Tejeda

Blanco-Pérez

et al. 2021

Foods

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Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). These are more uncommon than IgE-mediated food allergies, their mechanisms remain largely unknown, and their diagnosis is mainly done by clinical history, due to the lack of specific biomarkers. In this review, we present the latest advances found in the literature about clinical aspects, the current diagnosis, and treatment options of non-IgE-GI-FAs. We discuss the use of animal models, the analysis of gut microbiota, omics techniques, and fecal proteins with a focus on understanding the pathophysiological mechanisms of these pathologies and obtaining possible diagnostic and/or prognostic biomarkers. Finally, we discuss the unmet needs that researchers should tackle to advance in the knowledge of these barely explored pathologies.

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Food protein–induced enterocolitis and alpha-1-antitrypsin deficiency

Cited by 2 publications

References 8 publications

Further Insights into the Gut Microbiota of Cow’s Milk Allergic Infants: Analysis of Microbial Functionality and Its Correlation with Three Fecal Biomarkers

Further Insights into the Gut Microbiota of Cow’s Milk Allergic Infants: Analysis of Microbial Functionality and Its Correlation with Three Fecal Biomarkers

Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

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