Food protein‐induced enterocolitis syndrome among children in northern Sweden—A retrospective review from 2004–2018

Abstract

Aim To describe clinical presentation and development of tolerance among children with Food protein‐induced enterocolitis syndrome (FPIES) in a population in northern Sweden. Methods A retrospective review of medical records of children presenting with FPIES symptoms from 1 January 2004, to 31 May 2018. Results Sixty children (65% boys) with FPIES were included. The estimated incidence gradually increased to 0.45% in 2016–2017. The most common food triggers were cow's milk (40%), fish (37%) and oat (23%). Symptoms presented in 31 (60%) children before 6 months and in 57 (95%) before 1 year of age. The median age for FPIES diagnosis was 7 (range 3–134) months and for fish FPIES 13 (range 7–134) months. By 3 years of age, 67% of children with FPIES to milk and oat but none of the children with fish FPIES had developed tolerance. Allergic conditions like eczema and asthma were reported in 52% of the children. Conclusion The cumulative FPIES incidence was 0.45% in 2016–2017. Most children presented with symptoms before 1 year of age, but the diagnosis was often delayed, especially for FPIES to fish. Tolerance development occurred at an earlier age when FPIES was triggered by milk and oat compared to fish.

Issue highlights

“…The candidates need to be the first authors of the papers, not older than 45 years of age and members of the Swedish Paediatric Society. We are delighted to announce that the prize for the best paper in 2023 will be shared by Elina Oldhoff for Human bocavirus 1 epidemiology in children in relation to virus load and codetection 2 and Magnus Öhlund for Food protein‐induced enterocolitis syndrome among children in northern Sweden—A retrospective review from 2004–2018 3 …”

Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives

“… 7 FPIES often presents when complementary foods are introduced in a child’s diet. 9 Infantile FPIES is reported to often resolve by the time school age is reached, mainly for milk and egg. 10 Therefore, the natural history of FPIES in infants is generally favorable.…”

Young investigator award 2023

“…Magnus published his paper on Food protein‐induced enterocolitis syndrome among children in northern Sweden—A retrospective review from 2004–2018 1 with Sara Liljeholm, Åsa Strinnholm and Anna Winberg. The authors described food protein‐induced enterocolitis (FPIES) and reported that the most common food triggers were cows' milk, fish and oats.…”