Food reward system: current perspectives and future research needs

Alonso‐Alonso, Miguel; Woods, Stephen C.; Pelchat, Marcia Levin; Grigson, Patricia S.; Stice, Eric; Farooqi, I. Sadaf; Khoo, Chor San; Mattes, Richard D.; Beauchamp, Gary K.

doi:10.1093/nutrit/nuv002

Cited by 208 publications

(118 citation statements)

References 107 publications

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“…DA is a major (nonhomeostatic) regulator of food intake behaviors (Alonso‐Alonso et al., 2015). In agreement with our hypothesis, the present investigation evidenced associations of DA gene methylation patterns with BMI, AO, and carbohydrate intake, which might serve as epigenetic biomarkers of feeding behavior attitudes, excessive adiposity, and fat deposition.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, it has been reported that similar to alcohol and other drugs of abuse, highly palatable foods (rich in sugars and fat) can trigger neuroadaptive responses in brain reward circuitries (Alonso‐Alonso et al., 2015). These effects can stimulate feeding behavior and related attitudes independent of energy status or overcome other signals of satiety and hunger, contributing to overeating and weight gain (Kenny, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

et al. 2018

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IntroductionDopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake.MethodsAn adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened.ResultsAfter applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p < 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E−08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p < 0.001) and carbohydrate (p < 0.001) intakes.ConclusionsThe results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

et al. 2018

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“…However, functional imaging in leptin deficient patients demonstrated altered responses to alimentary stimuli and their normalization after leptin replacement therapy [17]. Therefore, our data might reflect extended and indirect effects of LepR signalling on the entire food reward loop [18].…”

Section: Resultsmentioning

confidence: 73%

Impaired Striatal GABA Outflow in Leptin Receptor Deficient Rats - The Role of Glucose and K Channels

Neto¹,

Capetian²,

Schumacher³

et al. 2017

Open J Neurosci

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“…Alonso-Alonso et al8 recently described “food addiction”, explaining that food, like any other rewarding stimulus, has the potential to cause addictive behavior. Drugs and foods share certain traits, yet differ qualitatively and quantitatively.…”

Section: Review Of Relevant Researchmentioning

confidence: 99%

Combining pain therapy with lifestyle: the role of personalized nutrition and nutritional supplements according to the SIMPAR Feed Your Destiny approach

Gregori¹,

Muscoli²,

Schatman³

et al. 2016

JPR

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Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, omega-3 fatty acids, and curcumin supplementation as key elements in modulating the efficacy of analgesic treatments, including opioids. These main topics were addressed during the first edition of the Study In Multidisciplinary Pain Research workshop: “FYD (Feed Your Destiny): Fighting Pain”, held on April 7, 2016, in Rome, Italy, which was sponsored by a grant from the Italian Ministry of Instruction on “Nutraceuticals and Innovative Pharmacology”. The take-home message of this workshop was the recognition that patients with chronic pain should undergo nutritional assessment and counseling, which should be initiated at the onset of treatment. Some foods and supplements used in personalized treatment will likely improve clinical outcomes of analgesic therapy and result in considerable improvement of patient compliance and quality of life. From our current perspective, the potential benefit of including nutrition in personalizing pain medicine is formidable and highly promising.

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Food reward system: current perspectives and future research needs

Cited by 208 publications

References 107 publications

Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

Impaired Striatal GABA Outflow in Leptin Receptor Deficient Rats - The Role of Glucose and K Channels

Combining pain therapy with lifestyle: the role of personalized nutrition and nutritional supplements according to the SIMPAR Feed Your Destiny approach

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