The issue of food fraud, safety and contaminants remains a topic of public concern, as it has been aligned to potential food scarcity. However, nanotechnology presents a promising opportunity for improving various industries, including food, agriculture, and health. This article aims to examine the potential of nanotechnology in enhancing food safety in Ghana, and its efficacy in addressing prevalent food safety challenges. Nano‐based approaches, such as nano‐packaging, nano‐sensing, nano‐additives, and other nano‐techniques, are discussed as effective methods for addressing major and emerging food safety issues in Ghana, such as food contaminants, antimicrobial resistance, food fraud and adulteration, and poor sanitary conditions. Additionally, the ethical and safety implications of these nano‐based approaches and particles are also deliberated.