For society to achieve the Sustainable Development Goals, the agri-food industry needs a substantial sustainability transition toward food systems capable of delivering greater volumes of nutritious food, while simultaneously lowering the environmental footprint. This issue of AHV focuses on the big picture-on mechanisms of sustainability transition, from social innovation, to models of finance and institutional systems, and calls for business and agricultural researchers to transform the sector together. Contributors to this issue embrace a transdisciplinary outlook, including scientific, technical, social and political dimensions of agroecology. This issue is a call to action: to encourage the community of social entrepreneurs, ecosystem players and researchers to contribute analytical methods, experiences and scientific insights on emerging social innovations related to food, agriculture and rural-urban transformation.