Introduction : Adolescence is a time of tremendous physical growth and mental development, with high nutrient requirements. Ethiopia is among a country with high prevalence of nutritional deficiencies among the women of reproductive age group whilst adolescent girls from rural suffer from it disproportionally. However, there is dearth of evidence regarding the barriers that hinder adolescent girls to utilize the available nutritional interventions. Therefore, the current study aimed to qualitatively explore the range of barriers for the uptake of nutritional interventions among adolescent girls in rural communities of Tigrai, Northern Ethiopia. Methods and participants : An explorative qualitative study was employed among purposively selected adolescent girls and school teachers form rural districts of Tigrai region of Northern Ethiopian. Nine focused group discussions (FGDs) with adolescent girls (Five with in-school adolescents and four with out-school girls), thirteen in-depth interviews with adolescent girls (Seven in-school girls and six out-school girls) and in-depth interviews with six teachers were conducted using semi-structured guide. Data were audio-taped, transcribed verbatim in local language, translated into English and imported into ATLAS.ti version 7.5 qualitative data analysis software for coding and analysis. Results : Adolescents perceived that stunting, anemia and thinness are among the main nutritional problems in their community. Food insecurity, limited nutrition awareness in the community, limited access to water for drinking and gardening, high workload, service provider’s little attention for adolescents’ nutrition and food taboo were emerged as barriers for the uptake of adolescent girls nutritional interventions. Though limited in reach, available nutritional interventions include awareness creation, nutritional supplementation, and disease prevention. Conclusion : A range of barriers hinder adolescent girls to access nutritional interventions. Food insecurity poses a strong challenge to adolescent girls’ nutrition. As access to safe drinking water continues to be a considerable bottleneck for nutritional interventions, multi-sectoral response to integrate water, sanitation and hygiene (WASH) services is required. Bounded by food taboo, high burden of workload among the adolescent girls, women empowerment and nutritional status seem to be the unfinished agenda in resource limited settings such as the rural areas of Tigrai, Northern Ethiopia.