Street foods play an important role in the lives of urban residents in developing countries. Consequently, there has been a lot of research into the nutritional quality of street vended foods, and the safety and hygiene of these foods. Researchers in Ghana have focused not only on the safety and hygiene of street foods but also on the effectiveness of regulations of these foods. While these provide important knowledge base for policy and action, very little has been done on challenges to improve the quality of local street vended foods. This study presents qualitative data from key stakeholders (vendors, consumers, regulators), on the challenges and opportunities to improve the quality of street vended local foods. Results show several challenges that relate to the safety and hygienic conditions at preparation and sale environments, and issues with the local regulatory authorities, inadequate capital with its related challenges and insecure space for street food vendors. This research recommends that efficient and effective collaboration between all actors and relevant institutions could offer the vendors an opportunity and capacity to provide healthy, affordable and preferred local dishes of cultural value to consumers.