The globe has been subjected to an unprecedented health challenge in the form of COVID-19, indiscriminately impacting the global economy, global supply chains, and nations. The resolution of this unprecedented challenge does not seem to be in the short-term horizon but rather something the globe has to live with. Initial data provides for some insights on responses, precautions, and sustainability protocols and processes. The Food and Beverages Manufacturing sector in South Africa (SA) and globally is an expeditious respondent to the COVID-19 challenge. Food is essential for human existence, but the food value chain is subjected to significant COVID-19 risks. The Food and Beverage Sector Education and Training Authority is responsible for skills development in the Food and Beverages (FoodBev) Manufacturing Sector in South Africa and seeks to quantify Foodbev sustainability. This research paper reviews global literature, performs a high-level knowledge classification, with the aim of expedited awareness, knowledge sharing, and most importantly, quantification of an expedited response, within the FoodBev Manufacturing sector in SA. The research is contextualized via a SA sector-based instrument deployment and data analysis. The paper provides insights into COVID-19 impact, adaptations, and responses in the SA Food and Beverages Manufacturing sector.