Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil

Elewa, Yaser Hosny Ali; Mohamed, Amany Abdel-Rahman; Galal, Azza A.A.; El-naseery, Nesma I.; Ichii, Osamu; Kon, Yasuhiro

doi:10.1016/j.ecoenv.2018.11.082

Cited by 27 publications

(12 citation statements)

References 73 publications

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“…Thus, a decline in testosterone levels is a normal result of the decline in LH levels. Also, the reduction in the testosterone level may be attributed to oxidative damage of Leydig cells induced by ROS generation and depletion of antioxidant stores (Elewa et al., 2019) in testicular tissue. These alterations were supported by the pathological lesions recorded in the testicular tissue of all treated rats.…”

Section: Discussionmentioning

confidence: 99%

Comparative effect of administration and discontinuation of sildenafil and/or clomipramine on the hepatic, cardiac and testicular tissues of male rats

et al. 2021

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In this study, we examined the adverse consequences of prolonged treatment with sildenafil and/or clomipramine (CLO) on the hepatic, cardiac and testicular tissues of rats. Additionally, we investigated the potential effects of treatment discontinuation. To this end, 60 adult male rats were randomly assigned into six groups and were orally treated with 4.5 mg sildenafil /kg BW (SLD) and 9 mg/ kg BW (SHD), 2.25 mg CLO/kg BW (CLO), 4.5 mg sildenafil/kg BW + 2.25 mg CLO/kg BW (SLD‐CLO) and 9 mg sildenafil/kg BW + 2.25 mg CLO/kg BW (SHD‐CLO) while the control rats received 0.5 ml distilled water for 8 weeks. Then, five rats from each group were sacrificed and the other five rats were left untreated for another four weeks to recover from the drug treatment. Long‐term administration of sildenafil and/or CLO led to oxidative stress, inflammation and structural changes in the liver, heart and testis, reduction in sperm count and motility, an increase in abnormalities, and a reduction in serum testosterone, FSH and LH levels. All tested parameters returned to the normal state following the four‐week discontinuation of sildenafil. Additionally, all the alterations caused by long‐term administration of CLO, SLD‐CLO and SHD‐CLO were significantly improved during the recovery period.

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Section: Discussionmentioning

confidence: 99%

Comparative effect of administration and discontinuation of sildenafil and/or clomipramine on the hepatic, cardiac and testicular tissues of male rats

et al. 2021

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“…ab236466) was used as recommended by the manufacturer, and 3,3′‐Diaminobenzidine (DAB) was used as a chromogen. After counterstained with Mayer's haematoxylin, sections cover slipped with entellan and examined light microscopy (Leica DM1000) (Elewa et al., 2019).…”

Section: Methodsmentioning

confidence: 99%

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

Okkay

Çiçek

et al. 2021

Andrologia

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The aim of this study was to investigate the effects of Achillea millefolium extract in paclitaxel‐induced testicular toxicity in rats. The groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (200 mg/kg, orally for 14 consecutive days) and (4) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (400 mg/kg, orally for 14 consecutive days). Serum levels of testosterone, luteinising hormone and follicle‐stimulating hormone, as well as total antioxidant capacity and total oxidant status were measured one day after receiving the last dose of Achillea millefolium extract. Testicular superoxide dismutase activity, malondialdehyde, tumour necrosis factor alpha and interleukin‐1β levels, the expressions of nuclear factor kappa B and caspase‐3 were evaluated. In addition, testicular sections were evaluated histopathologically and 8‐hydroxy‐2′‐deoxyguanosine was detected immunohistochemically. Achillea millefolium improved the levels of luteinising hormone, follicle‐stimulating hormone and testosterone, upregulated testicular antioxidant enzymes and downregulated inflammation. Furthermore, we observed that Achillea millefolium restored testicular histopathological structure and significantly suppressed oxidative DNA damage and apoptosis by reducing the expression of caspase‐3. Taken together, our results suggest that Achillea millefolium has protective effects against paclitaxel‐induced testicular toxicity and is a promising natural product with the potential to improve male fertility.

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“…RJ could be protective against the negative effects of flunixin meglumine-induced sperm toxicity in the male reproductive system [188]. The co-administration of RJ and cod liver oil could improve the biochemical, hormonal, and structural aspects of testicular tissue in food yellow 4 (FY4)-induced rats [107]. The co-administration could effectively improve sperm characteristics and early embryo development as well as the sperm lipid peroxidation level by acting as a promising reproductive agent in heat-stress conditions [189].…”

Section: Effect On Fertilitymentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil

Cited by 27 publications

References 73 publications

Comparative effect of administration and discontinuation of sildenafil and/or clomipramine on the hepatic, cardiac and testicular tissues of male rats

Comparative effect of administration and discontinuation of sildenafil and/or clomipramine on the hepatic, cardiac and testicular tissues of male rats

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

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