Foods With Added Fiber Lower Serum Creatinine Levels in Patients With Chronic Kidney Disease

Salmean, Younis; Segal, Mark S.; Langkamp‐Henken, Bobbi; Canales, Mary K.; Zello, Gordon A.; Dahl, Wendy J.

doi:10.1053/j.jrn.2012.04.002

Cited by 60 publications

(44 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As reported previously, nephrology patient charts (n = 270) were screened for eligible participants using the inclusion criteria: > 18 y, eGFR of ≤ 50 mL/min/1.73 m 2 (stage 3, 4 and 5 but not on dialysis), no acute kidney injury or glomerulonephritis, and no immunosuppressant medications [16]. Participants with CKD were provided with control foods (cookies, snack bars and breakfast cereal) containing < 2 g/day of fiber for 2 weeks, followed by similar foods providing 23 g/day (pea hull, inulin and resistant corn dextrin) for 4 weeks, to incorporate into their usual diets.…”

Section: Resultsmentioning

confidence: 99%

“…Participants with CKD were provided with control foods (cookies, snack bars and breakfast cereal) containing < 2 g/day of fiber for 2 weeks, followed by similar foods providing 23 g/day (pea hull, inulin and resistant corn dextrin) for 4 weeks, to incorporate into their usual diets. Four weeks was chosen for the length of the fiber intervention to allow for potential changes in gut microbiota, and its predicted impacts on previously reported outcomes [16], whereas the control was limited to 2 weeks to minimize participant burden. Participants completed the Kidney Disease Quality of Life (KDQOL-36) questionnaire [17], the Simplified Nutritional Appetite Questionnaire (SNAQ) [18] and the Epworth Sleepiness Scale [19] bi-weekly at clinic visits, and the Gastrointestinal Symptom Rating Scale (GSRS) [20], weekly.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Foods with added fiber improve stool frequency in individuals with chronic kidney disease with no impact on appetite or overall quality of life

2013

View full text Add to dashboard Cite

BackgroundFiber intake may be low in individuals with chronic kidney disease (CKD) due to diet restriction and/or poor appetite associated with uremic symptoms, contributing to constipation and reduced quality of life. This report describes the effects of foods with added fiber on gastrointestinal function and symptoms, clinical markers, and quality of life in CKD patients.FindingsAdults with CKD (n = 15; 9 F, 6 M; 66 ± 15 y) were provided with cereal, cookies and snack bars without added fiber for 2 weeks, followed by similar foods providing 23 g/d of added fiber for 4 weeks, to incorporate into their usual diets. Participants completed the Kidney Disease Quality of Life (KDQOL-36) questionnaire, the Simplified Nutritional Appetite Questionnaire (SNAQ) and the Epworth Sleepiness Scale (ESS) bi-weekly, the Gastrointestinal Symptom Rating Scale (GSRS) weekly, and daily stool frequency and compliance. Control and intervention serum cholesterol and glucose were assessed. Providing 23 g/d of added fiber increased stool frequency (1.3 ± 0.2 to 1.6 ± 0.2 stools/d; P = 0.02), decreased total cholesterol (175 ± 12 to 167 ± 11 mg/dL; P = 0.02) and improved TC:HDL ratio (4.0 ± 0.3 to 3.7 ± 0.2; P = 0.02). GSRS and SNAQ scores did not change, but SNAQ scores suggested poor appetite in 7 participants with or without added fiber. KDQOL Mental Health Composite decreased from 53 ± 2 to 48 ± 2 (P = 0.01) while Physical Health Composite increased from 31 ± 2 to 35 ± 3 (P = 0.02), with no change in overall QOL. The ESS score decreased from 10 ± 1 to 8 ± 1 (P = 0.04).ConclusionConsuming foods with added fiber may be an effective means of increasing fiber intakes, improving stool frequency, and lipid profile in individuals with CKD.Trial registrationClinicalTrials.gov, # NCT01842087

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Foods with added fiber improve stool frequency in individuals with chronic kidney disease with no impact on appetite or overall quality of life

2013

View full text Add to dashboard Cite

show abstract

“…Supporting this concept, several studies with small sample sizes have described an association between dietary fiber intervention and reductions of BUN and an increase in fecal nitrogen excretion in patients with CKD (19)(20)(21)(22)(23). Serum creatinine concentration decreased and eGFR increased after 4 weeks of 16.5 g/d added fiber in 13 patients with stages 3-5 CKD (23).…”

Section: Discussionmentioning

confidence: 99%

“…Consumption of fiber, which increases the energy substrate available to fecal bacteria and stimulates their proliferation, could reduce serum urea by providing a fecal route of excretion for accumulated nitrogenous wastes. Both animal (25,26) and human studies (19)(20)(21)(22)(23) have shown that fiber supplementation increases nitrogen excretion in feces and decreases serum nitrogen. Another hypothesis is that foods with fiber are also rich in antioxidants and vitamins (27), which could also relate to or influence the associations reported here.…”

Section: Discussionmentioning

confidence: 99%

Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk

Huang

Risérus

et al. 2014

Clinical Journal of the American Society of Nephrology

120

View full text Add to dashboard Cite

Background and objectives In the United States population, high dietary fiber intake has been associated with a lower risk of inflammation and mortality in individuals with kidney dysfunction. This study aimed to expand such findings to a Northern European population.Design, setting, participants, & measurements Dietary fiber intake was calculated from 7-day dietary records in 1110 participants aged 70-71 years from the Uppsala Longitudinal Study of Adult Men (examinations performed during 1991-1995). Dietary fiber was adjusted for total energy intake by the residual method. Renal function was estimated from the concentration of serum cystatin C, and deaths were registered prospectively during a median follow-up of 10.0 years.Results Dietary fiber independently and directly associated with eGFR (adjusted difference, 2.6 ml/min per 1.73 m 2 per 10 g/d higher; 95% confidence interval [95% CI], 0.3 to 4.9). The odds of C-reactive protein .3 mg/L were lower (linear trend, P=0.002) with higher fiber quartiles. During follow-up, 300 participants died (incidence rate of 2.87 per 100 person-years at risk). Multiplicative interactions were observed between dietary fiber intake and kidney dysfunction in the prediction of mortality. Higher dietary fiber was associated with lower mortality in unadjusted analysis. These associations were stronger in participants with kidney dysfunction (eGFR,60 ml/min per 1.73 m 2 ) (hazard ratio [HR], 0.58; 95% CI, 0.35 to 0.98) than in those without (HR, 1.30; 95% CI, 0.76 to 2.22; P value for interaction, P=0.04), and were mainly explained by a lower incidence of cancer-related deaths (0.25; 95% CI, 0.10 to 0.65) in individuals with kidney dysfunction versus individuals with an eGFR$60 ml/min per 1.73 m 2 (1.61; 95% CI, 0.69 to 3.74; P value for interaction, P=0.01).Conclusions High dietary fiber was associated with better kidney function and lower inflammation in community-dwelling elderly men from Sweden. High dietary fiber was also associated with lower (cancer) mortality risk, especially in individuals with kidney dysfunction.

show abstract

“…These are sources of dietary fiber, with likely numerous therapeutic benefits in CKD, particularly its role in targeting the gut microbiota 21 and reducing uremic toxin production as well as the risk of mortality and end-stage renal disease progression. 19,22,23 Increasing fruit and vegetable intake also conveys vitamins and antioxidants, with its purported benefits and typically deficient in the CKD patient. 24 Finally, increasing fruit and vegetable intake presents provocative potential for prevention of metabolic acidosis, with parallel benefits for blood pressure and weight control compared with a prescription of sodium bicarbonate.…”

Section: Y Ou Are Whatyou Eat the American Nutritionistmentioning

confidence: 99%

Diet for the Management of Patients With Chronic Kidney Disease; It Is Not the Quantity, but the Quality That Matters

Campbell

Carrero

2016

Journal of Renal Nutrition

View full text Add to dashboard Cite

Foods With Added Fiber Lower Serum Creatinine Levels in Patients With Chronic Kidney Disease

Cited by 60 publications

References 11 publications

Foods with added fiber improve stool frequency in individuals with chronic kidney disease with no impact on appetite or overall quality of life

Foods with added fiber improve stool frequency in individuals with chronic kidney disease with no impact on appetite or overall quality of life

Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk

Diet for the Management of Patients With Chronic Kidney Disease; It Is Not the Quantity, but the Quality That Matters

Contact Info

Product

Resources

About