Recently, it has become an important issue to ensure sustainability, especially in food supply chains, against the rapidly growing population, increasing demand, and sudden disruptions caused by uncertain times such as that caused by COVID-19. Since food supply chains has vulnerable products and processes, it is critical to understand the sustainability factors of food supply chains especially in uncertain times such during the COVID-19 pandemic. This study aims to determine sustainability factors of food supply chains. An Interpretive Structural Modelling method is used to state the relations between sustainability factors of food supply chains. As a result of the study, Information Sharing and Managerial Approaches are classified as driving factors; Food Safety and Security, Know-How Transfer, Logistics Networking, Risk Mitigation, Employee Commitment, Innovation, Traceability and Responsiveness are categorized as linkage factors. This article will be beneficial for managers in helping them develop sustainable food supply chains during uncertain times by focusing on traceability, information sharing, know-how transfer, food safety and security.