Based on the configuration theory of screw theory, this paper designs and develops a new multi-mode moving mechanism. The mechanism consists of two planar single-loop four-bar mechanisms arranged symmetrically in space. According to the requirements of different road conditions, it can realize three movement modes of sliding, rolling and crawling. First, the spatial 3R (revolute pair) kinematic branch chain is constructed that based on the 2R branch chain by screw theory. Then, based on the spatial line geometry theory and the position relation of the axis of the kinematic pair of the spatial 3R kinematic branch chain, the spatial single-loop four-bar linkage is synthesized. To realize the design requirements of multi-mode mobile mechanism, one of the planar single-loop four-bar structures is selected as the basic framework. Finally, the feasibility of freedom degree and motion mode of the mechanism is analyzed. The results of simulation and experimental which are carried out by SolidWorks shows that the mechanism can adapt to a variety of complex road conditions and has good maneuverability, and this method is useful for the design of multimode mobile mechanisms.