Background: Classification of infants into low birth weight (LBW, o2500 g) or very low birth weight (VLBW, o2000 g) categories is a crucial step in targeting interventions to high-risk infants. Objective: To compare the validity of chest circumference and foot length as surrogate anthropometric measures for the identification of LBW and VLBW infants. Subjects and setting: Newborn infants (n ¼ 1640) born between March and June 2004 in 30 Village Development Committees of Sarlahi district, Nepal. Design: Chest circumference, foot length and weight (SECA 727, precise to 2 g) of newborns were measured within 72 h after birth. The sensitivity, specificity and predictive values for a range of cutoff points of the anthropometric measures were estimated using the digital scale measurements as the gold standard. Results: Among LBW infants (469/1640, 28.6%), chest circumference measures o30.3 cm were 91% sensitive and 83% specific. Similar levels of sensitivity for foot length were achieved only with considerable loss of specificity (o45%). Foot length measurements o6.9 cm were 88% sensitive and 86% specific for the identification of VLBW infants. Conclusion: Chest circumference was superior to foot length in classification of infants into birth weight categories. For the identification of VLBW infants, foot length performed well, and may be preferable to chest circumference, as the former measure does not require removal of infant swaddling clothes. In the absence of more precise direct measures of birth weight, chest circumference is recommended over foot length for the identification of LBW infants.