Footprints of microRNAs in Cancer Biology

Rajasegaran, Yaashini; Aziz, Azlan Abdul; Rosli, Aliaa Arina; Yik, Mot Yee; Zi, Khor Kang; Yusoff, Narazah Mohd; Moses, Emmanuel Jairaj

doi:10.3390/biomedicines9101494

Cited by 12 publications

(9 citation statements)

References 254 publications

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“…Previously, it was thought that only defects in tumor promoter and tumor suppressive genes play a role in the formation of cancer (Rajasegaran et al 2021). However, with the discovery of miRNA molecules, diagnostic, prognostic, and therapeutic approaches against cancer gained a new dimension (Rajasegaran et al 2021). Accumulating evidence indicates that these small RNA molecules are highly deregulated in human cancers.…”

Section: Mirnas and Cancermentioning

confidence: 99%

miRNAs, cancer, and unconventional miRNA functions

Bozgeyik

2023

Bulletin of Biotechnology

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MicroRNAs are non-protein-coding RNA molecules that control and fine-tune gene expression at the post-transcriptional level by negatively regulating their target genes. MicroRNAs mature into 22-nucleotide-long RNA transcripts that negatively regulate gene expression by inducing either inhibition of translation or degradation of mRNAs. Increasing evidence suggests that distinct signatures of microRNAs are a feature of human cancers. MicroRNA expression patterns have been linked to tumor development, progression, and response to therapies, implying that they could be used as prognostic and diagnostic biomarkers. Moreover, based on a growing body of research indicating that microRNAs may serve as tumor suppressive or tumor promoter functions, miRNA-based therapy against cancer has lately been utilized, either alone or in conjunction with current targeted strategies. One of the advantages of microRNA-based therapeutics is that they can target numerous components of signaling circuits involved in cell differentiation, proliferation, and survival. In this review, the current available evidence about miRNAs and their diagnostic, prognostic, and therapeutic potential will be discussed. miRNAs may play chief roles in the development and progression of human cancers, offer great advantages in differential diagnosis, and can be therapeutically targeted.

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Section: Mirnas and Cancermentioning

confidence: 99%

miRNAs, cancer, and unconventional miRNA functions

Bozgeyik

2023

Bulletin of Biotechnology

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“…Comprehensive understanding of the molecular basis of NPC is necessary to improve treatment and prognosis. Dysregulation of miRNAs signature has been reported in many cancers including NPC, because of the involvement of miRNAs in the regulation of many crucial biological processes 4–6 …”

Section: Introductionmentioning

confidence: 99%

“…miRNAs are small and conserved noncoding RNA molecules consisting of 20–22 nucleotides that regulate genes at the level of posttranscription by reducing the targeted mRNAs to induce the partial complementarity of 3′‐untranslated regions. Various pieces of evidence has suggested that miRNAs could function either as onco‐miR or as tumor suppressors‐miR during cancer development 5,7 . miRNAs work in homeostasis under healthy physiological conditions by protecting and regulating biological activities.…”

Section: Introductionmentioning

confidence: 99%

Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F signaling pathways: A review

S. M. N. Mydin,

Azlan,

Okekpa

et al. 2024

Cell Biochemistry & Function

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MicroRNAs (miRNA) are small and conserved noncoding RNA molecules that regulate gene expression at the posttranscriptional level. These groups of RNAs are crucial in various cellular processes, especially in mediating disease pathogenesis, particularly cancer. The dysregulation of miRNAs was reported in many cancer types, including nasopharyngeal cancer (NPC), which is a malignant tumor of the nasopharynx. In this review, miRNAs involvement in crucial signaling pathways associated with NPC such as PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F was investigated. miRNAs could function as tumor suppressor‐miR or onco‐miR in NPC profoundly influenced cell cycle, apoptosis, proliferation, migration, and metastasis. This comprehensive review of current literature provided a thorough profile of miRNAs and their interplay with the aforementioned signaling pathways in NPC. Understanding these molecular interactions could remarkably impact the diagnosis, prognosis, and therapeutic strategies for NPC.

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“…miRNAs can modulate the function of various cells and are involved in the pathophysiology of responses to viral infections [ 4 , 5 ] and respiratory diseases [ 6 , 7 ]. In addition, these molecules have been used as biomarkers of diverse diseases [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Mir-150-3p Expression Is Associated with Radiological Lung Injury Improvement in Patients with COVID-19

Buéno

Paim

Minin

et al. 2022

Viruses

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Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the association between circulating miRNAs and lung injury associated with COVID-19. Methods: We evaluated lung injury by computed tomography at hospital admission and discharge and the serum expression of 754 miRNAs using the TaqMan OpenArray after hospital discharge in 27 patients with COVID-19. In addition, miR-150-3p was validated by qRT-PCR on serum samples collected at admission and after hospital discharge. Results: OpenArray analysis revealed that seven miRNAs were differentially expressed between groups of patients without radiological lung improvement compared to those with lung improvement at hospital discharge, with three miRNAs being upregulated (miR-548c-3p, miR-212-3p, and miR-548a-3p) and four downregulated (miR-191-5p, miR-151a-3p, miR-92a-3p, and miR-150-3p). Bioinformatics analysis revealed that five of these miRNAs had binding sites in the SARS-CoV-2 genome. Validation of miR-150-3p by qRT-PCR confirmed the OpenArray results. Conclusions: The present study shows the potential association between the serum expression of seven miRNAs and lung injury in patients with COVID-19. Furthermore, increased expression of miR-150 was associated with pulmonary improvement at hospital discharge.

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Footprints of microRNAs in Cancer Biology

Cited by 12 publications

References 254 publications

miRNAs, cancer, and unconventional miRNA functions

miRNAs, cancer, and unconventional miRNA functions

Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F signaling pathways: A review

Increased Serum Mir-150-3p Expression Is Associated with Radiological Lung Injury Improvement in Patients with COVID-19

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