Objective: Based on the Conservation of Resources theory, this cross-sectional study investigates the relationship between workload experienced by employees when working at home and their mental well-being. Work-family conflict, sleeping problems, and work engagement are proposed as mediators. Methods: A sample of 11,501 homeworkers was drawn from the sixth wave of the European Working Condition Survey data set. Results: Unlike the expected, the higher the workload, the higher the mental well-being of employees. However, as expected, high workload was correlated with lower well-being when indirect effects through work-family conflict, sleep problems, and work engagement were considered. Similarly, the total effect of workload on mental well-being was negative. Conclusions: The study suggests that organizations should pay more attention to the amount of workload experienced by their homeworkers because it may be harmful to their health and well-being.