Forage Legumes as Sources of Bioactive Phytoestrogens for Use in Pharmaceutics: A Review

Tucak, Marijana; Horvat, Daniela; Čupić, Tihomir; Krizmanić, Goran; Tomaš, Vesna; Ravlić, Marija; Popović, Svetislav

doi:10.2174/1389201019666180730165917

Cited by 28 publications

(18 citation statements)

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“…Phytoestrogens are compounds that have weak estrogenic effects in plants and are known to be present in several different types of food, such as grains, beans, fruits, vegetables, and, in particular, many soy products [114,115]. The three major classes of phytoestrogens in the human body are lignan, isoflavones (daidzein, genistein, and glycitein), and coumestans (coumestrol).…”

Section: Phytoestrogensmentioning

confidence: 99%

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Tang

Deng

et al. 2020

IJMS

130

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Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.

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Section: Phytoestrogensmentioning

confidence: 99%

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Tang

Deng

et al. 2020

IJMS

130

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“…Many factors affect the content of phytoestrogens including genetic factors (plant genotype), environmental conditions (temperature, rainfall, humidity, sunlight), biotic factors (fungal diseases), stages of maturity (early vegetative-late flower), stand age of alfalfa, plant parts (leaves, stems and flowers), management strategies (cutting frequency), and preservation method [16,26,33,34]. Conducted studies and currently available data on quantification of the phytoestrogen content in alfalfa show that their amount is highly variable and results are very often inconsistent [35,36]. Martin et al [37] found that the highest average content of coumestrol was 99 µg g −1 of DM, followed by formononetin, daidzein, biochanin A, and genistein with 43, 21, 19, and 14 µg g −1 of DM, respectively.…”

Section: Phytoestrogen Contentmentioning

confidence: 99%

Variation of Phytoestrogen Content and Major Agronomic Traits in Alfalfa (Medicago sativa L.) Populations

et al. 2020

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Alfalfa is the main perennial legume and a rich source of phytoestrogens. Variation of phytoestrogen content and agronomic traits was evaluated in twenty alfalfa populations over two consecutive years. The most dominant phytoestrogen in alfalfa populations was genistein, while slightly lower levels were found for kaempferol and coumestrol. Several populations (Af 1, 12, 18, 19, 20) showed superior agronomic performance, especially high forage yield (up to 71.93 t ha−1). These populations were also characterized by a lower (Af 1, 12, 18, 20) or high (Af 1, 19) content of total and individual phytoestrogens, including Af 8 population with the highest total content (2637.10 μg g-1 of DM) and content of most of the individual phytoestrogens and favorable agronomic properties. Ward hierarchical clustering method grouped the twenty evaluated populations into four distinct clusters. Identified materials provide a valuable source of germplasm for further breeding programs in order to develop new high-yielding cultivars with either low (for forage use) or high (for possible pharmaceuticals/nutraceuticals industries) phytoestrogen content.

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“…Its use as an alternative source of isoflavones became interesting for the scientific community over the last few decades because of the several key reasons, such as the following ones: a possibility of sustainable and environmentally friendly production; a limited use of soybean, presently a major source of isoflavonoids in human nutrition due to the allergenic reactions it can cause in some people; a steady increase in the production area of genetically modified soybean notwithstanding a fact that many people and scientists do not approve the use of such plants (Aparicio-Fernandez et al, 2005;Saviranta et al, 2008;Dabkevičiene et al, 2012;Butkute et al, 2014;Tucak et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Karakterizacija sadržaja izoflavona u hrvatskoj kolekciji crvene djeteline

Tucak

Popović

Horvat

et al. 2019

Poljoprivreda (Online)

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Red clover is a perennial forage crop rich in isoflavones, the bioactive compounds with a positive effect on human and animal health. The aim of the research was to determine a variation in the isoflavone contents in the Croatian red clover collection and to identify the most promising materials to be used in the breeding program for the development of new cultivars for specific purposes. Leaf samples of 29 red clover cultivars/populations (two cultivars, twenty breeding populations, and seven local populations) were collected in a full flowering stage, and the identification and quantification of isoflavones was performed using the HPLC analysis. The most common isoflavones in the red clover cultivars/populations were formononetin and biochanin A. A significant variation among the cultivars/populations in the total and individual isoflavone content was determined. The populations with very high and low contents of both the total and of the individual isoflavones were identified to be used for the breeding purposes in order to develop new forage cultivars, or for specific goals in the pharmaceutical industry.

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Forage Legumes as Sources of Bioactive Phytoestrogens for Use in Pharmaceutics: A Review

Cited by 28 publications

References 0 publications

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

Variation of Phytoestrogen Content and Major Agronomic Traits in Alfalfa (Medicago sativa L.) Populations

Karakterizacija sadržaja izoflavona u hrvatskoj kolekciji crvene djeteline

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