Forage plant estrogens

Livingston, A. L.

doi:10.1080/15287397809529663

Cited by 77 publications

(15 citation statements)

References 96 publications

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“…Both these compounds are abundant in many food sources (Livingston, 1978;Verdeal and Ryan, 1979;Kuiper-Goodman et al, 1987), bind to the human ER with a relatively high affinity (Miksicek, 1994), and stimulate growth in estrogen sensitive cell lines (Mayr et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Knudsen

Pottinger

1998

Aquatic Toxicology

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Contact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. AbstractThe ability of chemicals with known endocrine disrupting activity to interact with three major teleost steroid-binding sites was evaluated. Representative alkylphenols and phthalates, the pesticides dieldrin and toxaphene, the mycoestrogen zearalenone and the phytoestrogen genistein were tested for their ability to displace native ligand from putative estradiol receptor (ER), testosterone receptor (TR) and cortisol receptor (CR) from rainbow trout liver and brain. The ER displayed a higher affinity for alkylphenols than for phthalates, but both groups of compounds were 10 4 -2.10 5 times less potent than estradiol in displacing specifically bound

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Section: Discussionmentioning

confidence: 99%

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Knudsen

Pottinger

1998

Aquatic Toxicology

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“…However, others think that endocrine-active chemicals do not pose a significant health risk, particularly in view of the fact that hormone mimics exist in the natural environment. Examples of natural hormone mimics are the isoflavinoid phytoestrogens (Adlercreutz 1995;Livingston 1978;Mayr et al 1992). These chemicals are derived from plants and are similar in structure and action to endogenous estrogen.…”

Section: Toxicities Mediated Through the Neuroendocrine Axismentioning

confidence: 99%

Toxicological Profile for Zinc

2002

ATSDR's Toxicological Profiles

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“…They are collectively termed phytoestrogens, comprising isoflavones, coumestans and lignans, of which isoflavones in soybeans and coumestans in Medicago species such as alfalfa, are well-known (Livingston, 1978;Fletcher, 2003;Dixon, 2004). The oestrogenic substance zearalenone is also found in Fusarium species of fungi, which are common contaminants of cereals (Zinedine et al, 2007;EFSA Journal 2010;8(11):19328(11): Mantovani et al, 2009.…”

Section: Exposure To Naturally Occurring Easmentioning

confidence: 99%

Scientific report of the Endocrine Active Substances Task Force

2010

EFSA Journal

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Discussions within the Scientific Committee and the Advisory Forum have called for the development of a common approach within EFSA towards endocrine active substances. The aim of this report by an internal EFSA task force is to clarify the state-of-play, and provide recommendations for scientific and communication issues. Both specific issues and new regulations make it necessary to follow up on recent developments with the EU bodies, Member States, and internationally, in order to avoid diverging assessment approaches and the duplication of work. The proposed actions for EFSA are to contribute to the work in progress under the auspices of DG Environment and to continue its participation in the ongoing OECD activities in the area of testing of chemicals. The development of a generally accepted risk assessment methodology is an additional challenge due to the complexity of the issues involved. Here, the task force recommends that EFSA continues its activities aimed at developing harmonised methodologies for risk assessment of combined exposures to endocrine active substances in food. EFSA should continue to build a dialogue to develop a common strategy with the EC, other EU bodies, Member States' Competent Authorities, international organisations and partners, as well as external experts and stakeholders on the before mentioned issues. In line with these recommendations, it is proposed that EFSA creates a working group of Panel experts and national experts to advise on prioritising the work on endocrine active substances. EFSA should also work with the experts in its Advisory Group on Risk Communications in conjunction with the communication experts from Member States, and continues to monitor and analyse media and stakeholder developments, in order to define a strategy for communications addressing both the collective group and specific endocrine active substances. © European Food Safety Authority, 2010 KEY WORDSEndocrine active substances, endocrine disrupters, hazard identification, risk assessment, method harmonisation, common strategy, risk communication SUMMARYThe issue of endocrine active substances touches upon the activities of several of the EFSA Units and Panels, recent examples being the risk assessment of bisphenol A, the hazard assessment of isoflavones and the implementation of the new regulation on plant protection products. Previous examples include contaminants like organotins, dioxins, PCBs, and hormone residues.Discussions within the Scientific Committee and the Advisory Forum have called for the development of a common approach within EFSA towards endocrine active substances. A first step in this process was to appoint a task force to identify trends and developments in the assessment of the health risks and risk communication issues EFSA may have to address. The aim of this report by the task force is to clarify the state-of-play, and provide recommendations for the scientific and communication issues.Current activities and developments within EFSA, European Commission, other Europ...

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Forage plant estrogens

Cited by 77 publications

References 96 publications

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Toxicological Profile for Zinc

Scientific report of the Endocrine Active Substances Task Force

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