Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

Talianu, Marina-Theodora; Dinu-Pîrvu, Cristina-Elena; Ghica, Mihaela Violeta; Anuța, Valentina; Jinga, Viorel; Popa, Lăcrămioara

doi:10.3390/nano10112292

Cited by 16 publications

(18 citation statements)

References 302 publications

(343 reference statements)

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“…There are generally two types of microemulsions which are the oil-in-water and the water-in-oil emulsion where the first component represents the dispersed phase and the latter component is the dispersing phase (Figure 12). [132] The surfactants are known to be amphiphilic because they comprise of a polar head group a non-polar tail region, and are located at the oil/water interface. [133] Shao et al [134] report the use of norcantharidin, surfactants (Tx13 and Tw80), and cosurfactant (ethanol) as microemulsion which serve as biopesticides for diamondback moth.…”

Section: Microemulsion and Nanomicellesmentioning

confidence: 99%

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Nanomaterials as Nanofertilizers and Nanopesticides: An Overview

Okey-Onyesolu

Hassanisaadi²,

Bilal

et al. 2021

ChemistrySelect

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Nanotechnology has acquired increasing interest recently in agriculture and crop production for achieving proficient utilization of resources by developing nanodelivery systems for agrochemical products or sensors (for nutrient status or water). The development of new nanofertilizers provides a promising opportunity to improve plant mineral nutrition. According to the reports, nanostructured materials are more efficient than traditional fertilizers, with a site-specific and controlled release of nutrients that not only increased the efficacy of plant uptake but also reduced negative environmental effects due to the loss of nutrients into the environmental matrices. In this section, we illustrate various kinds of novel nanostructured materials as promising carriers for nutrients such as nanoclays, carbon nanodots, carbon nanotubes, and nanofibers, hydroxyapatite nanoparticles, carbon-based nanomaterials, and polymeric nanoparticles. Also, the impact of nanomaterials on pesticides is discussed. They play a great contribution to enhancing agricultural productivity involving for gradual release and proper pesticide dosage to aid pest control. Different nanomaterials used are discussed contributing to the reduction of the exposure of humans to pesticides.

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Section: Microemulsion and Nanomicellesmentioning

confidence: 99%

“…Two schematic models of microemulsions with oil-in-water and the water-in-oil structure. [132] Figure 13. Schematic structure of a micelle.…”

Section: Polymeric Nanocarriersmentioning

confidence: 99%

Nanomaterials as Nanofertilizers and Nanopesticides: An Overview

Okey-Onyesolu

Hassanisaadi²,

Bilal

et al. 2021

ChemistrySelect

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“…Pronounced keratolytic effects are wielded in a concentration domain of 2-10% [8], while concentrations up to 30% are used in peeling procedures [9]. Acne represents a dermatologic condition with an inflammatory component, targeting sebaceous glands [10,11]. Its multifactorial character and high recurrence among adolescents, and also adult patients, suggest acne is a complex pathology [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Acne represents a dermatologic condition with an inflammatory component, targeting sebaceous glands [10,11]. Its multifactorial character and high recurrence among adolescents, and also adult patients, suggest acne is a complex pathology [11,12]. Tissue disorder, which collapses with the development of scarring, is the result of the simultaneous action of hormonal, immunological, microbiological, and genetic factors [13].…”

Section: Introductionmentioning

confidence: 99%

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

et al. 2022

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The present study brings to attention a method to develop salicylic acid-based oil in water (O/W) microemulsions using a tensioactive system based on Tween 80, lecithin, and propylene glycol (PG), enriched with a vegetable oat oil phase and hyaluronic acid. The systems were physically characterized and the Quality by design approach was applied to optimize the attributes of microemulsions using Box–Behnken modeling, combined with response surface methodology. For this purpose, a 33 fractional factorial design was selected. The effect of independent variables namely X1: Tween 80/PG (%), X2: Lecithin (%), X3: Oil phase (%) was analyzed considering their impact upon the internal structure and evaluated parameters chosen as dependent factors: viscosity, mean droplet size, and work of adhesion. A high viscosity, a low droplet size, an adequate wettability—with a reduced mechanical work—and clarity were considered as desirable for the optimal systems. It was found that the optimal microemulsion which complied with the established conditions was based on: Tween 80/PG 40%, lecithin 0.3%, oat oil 2%, salicylic acid 0.5%, hyaluronic acid 1%, and water 56.2%. The response surface methodology was considered an appropriate tool to explain the impact of formulation factors on the physical properties of microemulsions, offering a complex pattern in the assessment of stability and quality attributes for the optimized formulation.

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“…For acne alleviation, various molecules were entrapped in microemulsion systems. Their optimized composition can promote superior delivery compared with conventional formulations [58]. Here, the association between S and CoS will assure supplementary disruptive effects at cellular level, due to their property of penetration enhancement [69].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study Regarding the Formulation and Physical Evaluation of Some Biocompatible, Oil in Water Microemulsions With Salicylic Acid for Dermatologic Use

Anicescu¹

2021

FARMACIA

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Microemulsions (MEs) are considered a piece of new generation colloidal systems with high potential for drug delivery, especially for topical application. The present study had as main objectives the development and physical analysis of two groups of oil in water (O/W) microemulsion (ME) vehicles using a biocompatible mixture composed of lecithin/Tween 80 as surfactants and propylene glycol (PG) as cosurfactant. The addition of vegetable oils and hyaluronic acid (HA) enriched the quality profile of the systems. The vehicles were suitable to entrap salicylic acid (SA) 0.5% as a model drug with keratoplastic properties, and positive outcomes in acne treatment. The study was divided in two stages of screening, resulting two groups of MEs. In the first case, lecithin was tested as potential surfactant on a domain of 0.5 -2%. A minimum amount of lecithin 0.5%, in association with Tween 80 and PG was considered appropriate to obtain the second group of O/W MEs. In this case, were screened combinations of lecithin/Tween 80/PG able to solubilize SA 0.5% and small quantities of vegetable oils. All the microdispersions obtained in both stages were analysed considering visual appearance, conductivity, pH and refractive index as important parameters for systems' stability. The area of MEs generation for the second group, was specifically identified using graphical method. An extensive rheological analysis was considered to determine the flow behaviour for the most representative systems. It was concluded that minimal concentration of tensioactives that can promote stable and clear systems with SA was 30.5%. This proportion was specific for a ME system formulated with 20% Tween 80, 10%PG and 0.5% lecithin. Physical analysis performance emphasized preliminary data concerning the internal structure of microemulsions, offering a useful background for future studies. RezumatMicroemulsiile (MEs) reprezintă formulări ce aparţin noii generaţii de sisteme coloidale, cu înalt potenţial pentru cedarea medicamentului, în special pentru administrarea topică. Prezentul studiu a avut ca obiective principale dezvoltarea şi analiza fizică a două grupe de vehicule de tip microemulsie (ME) ulei în apă (U/A), utilizând un amestec biocompatibil format din lecitină/Tween 80 ca surfactanţi, alături de propilenglicol (PG) cu funcţie de cosurfactant. Au fost adăugate uleiuri vegetale şi acid hialuronic (HA), cu scopul de a îmbunătăţi profilul calitativ al sistemelor. Vehiculele formulate au fost adecvate pentru încorporarea acidului salicilic (SA) 0,5% ca medicament model cu proprietăţi keratoplastice și efecte pozitive în tratamentul acneei. Studiul a fost împărțit în două etape de screening, rezultând două grupe de microemulsii. În prima etapă, lecitina a fost testată ca potențial surfactant pe un domeniu de 0,5 -2%. Utilizarea lecitinei 0,5%, alături de Tween 80 și PG, a fost considerată potrivită pentru obținerea celui de-al doilea set de sisteme U/A. În acest caz, au fost testate combinații conținând lecitină/Tween 80/PG, capabile să solubilize...

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Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

Cited by 16 publications

References 302 publications

Nanomaterials as Nanofertilizers and Nanopesticides: An Overview

Nanomaterials as Nanofertilizers and Nanopesticides: An Overview

Insights from a Box–Behnken Optimization Study of Microemulsions with Salicylic Acid for Acne Therapy

Preliminary Study Regarding the Formulation and Physical Evaluation of Some Biocompatible, Oil in Water Microemulsions With Salicylic Acid for Dermatologic Use

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