Force-interval relationship in heart muscle of mammals. A calcium compartment model

Schouten, V. J. A.; Deen, J. K. Van; Tombe, Pieter de; Verveen, A. A.

doi:10.1016/s0006-3495(87)83307-6

Cited by 72 publications

(45 citation statements)

References 47 publications

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“…Although the physiological processes that underlie the force-interval relationship are not fully characterized, a number of investigators have demonstrated that developed force after an interposed beat is directly related to the amplitude of the calcium transient (34)(35)(36)(37). This observation has prompted authors to propose a model with, in its simplest form, functional uptake and release compartments for calcium (38)(39)(40). Generally speaking, these models propose that after a contraction calcium is taken up into the uptake compartment but can only be released from the release compartment.…”

Section: Discussionmentioning

confidence: 99%

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.

Marber¹,

Walker²,

Latchman³

et al. 1994

J. Clin. Invest.

117

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The aims of this study were to examine the effects of whole body heat stress and subsequent stress protein induction on glycolytic metabolism, mitochondrial metabolism, and calcium handling within the heart. The effect of heat stress on glycolytic and mitochondrial pathways was examined by measuring contractile performance in the presence of glucose and pyruvate, respectively. Calcium handling was assessed using force-interval relationships. Right ventricular papillary muscles taken from heat-stressed and control rabbit hearts were superfused with Kreb's solution containing either glucose or pyruvate and rendered hypoxic for 30 min. After reoxygenation, the greatest recovery of contractile function occurred in the heat-stressed muscles with pyruvate as substrate; there was, however, no difference in the force-interval relationship between the groups. The degree of contractile recovery was related to the content of the inducible 70-kD but not the 65-kD, heat stress protein. This study suggests that heat stress enhances the ability of rabbit papillary muscle to use pyruvate, but not glucose, after reoxygenation, and that the differences seen in contractility may be secondary to induction of the 72-kD stress protein.(J. Clin. Invest. 1994. 93:1087-1094

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Section: Discussionmentioning

confidence: 99%

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.

Marber¹,

Walker²,

Latchman³

et al. 1994

J. Clin. Invest.

117

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“…Our interpretation of the results is based on the current model of Ca 2+ transport in heart muscle fibers (1,32,37,39,48,50). Briefly, on excitation the sarcoplasmic retieulum releases its Ca 2+ content into the sarcoplasm, and peak force is proportional to the amount of released Ca 2+.…”

Section: Discussionmentioning

confidence: 98%

“…1). The exponential decay of potentiation is characterized by the decay constant, D, and can be described (39,50) by the empirical equation dP/dt(n + 1) = D x dP/dt(n) + constant,…”

Section: Basic Research In Cardiology !/Ol 85 No 6 (I990)mentioning

confidence: 99%

“…We used post-extrasystolic potentiation to analyze contractility since, according to current models of excitation-contraction coupling, it may give information about two important fundamental mechanisms (1,32,37,39,48,50): the degree of post-extrasystolic potentiation is thought to be proportional to the influx of Ca 2+ per action potential, whereas the fraction of Ca 2+ that recirculates via the reticulum from beat-to-beat depends on the rate of Ca 2+ uptake by the sarcoplasmic reticulum, and can be calculated from the decay of potentiation. This protocol was applied to all four types of preparations.…”

Section: Introductionmentioning

confidence: 99%

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Calcium metabolism and depressed contractility in isolated human and porcine heart muscle

et al. 1990

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Contractility is often depressed in isolated heart muscle. To analyze this phenomenon, we measured the derivative of left ventricular pressure (dP/dt) in intact and in isolated, blood perfused pig hearts, and peak force (F) or stress (F/mm2) in ventricular trabeculae of man and pig. When the heart was in the steady state at a priming frequency of 2 Hz an extrasystolic interval of 0.3 s was interposed, followed by four postextrasystolic intervals of 0.8 s. In the case of isolated trabeculae the priming frequency was 0.2 Hz, the extra interval 0.4 s, and the post-extrasystolic intervals were 5 s. The exponential decay of potentiation is characterized by the constant D: a low value of D indicates a rapid decay of potentiation. DP/dt was about 1000 mm Hg/s in the intact hearts, but within 1 h after isolation dP/dt decreased to about 700 mm Hg/s, and this was associated with a decrease in D from 0.63 to 0.40. Developed stress in the isolated trabeculae was about 2 mN/mm2 and D was about 0.20 under standard, in vitro conditions (a.o. 1.5 mM Ca2+. 0.2 Hz stimulus frequency). This stress is only 10% of the calculated stress in the intact heart. An increase of priming frequency, or of [Ca2+], or addition of 30 nM isoproterenol to the perfusate caused a marked increase in F and D. Properties of human and porcine trabeculae were quantitatively similar. The strong correlation between dP/dt, or F, and D suggests a causal relationship. This is consistent with the current model of e-c coupling in heart muscle, in which the activity of the Ca2+ pump of the sarcoplasmic reticulum determines the decay of potentiation and the amount of releasable Ca2+ in the reticulum determines force of contraction. Since isoproterenol stimulates the Ca2+ pump in the reticulum, the increase in D and F induced by this drug is consistent with the model. We conclude, that the decreased dP/dt, F, and D in isolated preparations was due to impaired sarcoplasmic reticulum function. The role of this phenomenon in the stunned heart syndrome, species differences and possible causes are discussed.

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“…There have been several studies concerning the force-interval relation of cardiac muscle but most have dealt with isolated hearts or papillary muscle and could not be applied directly to the in situ heart. [6][7][8][9] This difficulty is partly because the preceding interval and the contractile state of the previous beat may modulate the contractile state of the following contraction; thus, there is no means for determining LV contractility on a beat-to-beat basis when there are variations in loading conditions.…”

mentioning

confidence: 99%

Application of Mechanical Restitution

et al. 1998

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The effects of verapamil administration or vagal stimulation on the mechanical restitution curve (MRC) were studied in order to better understand the modulation of left ventricular (LV) function by interventions that lower the ventricular rate of atrial fibrillation. The MRC and the postextrasystolic MRC were obtained in 11 dogs using peak single beat elastance (Emax). The MRC was fitted by a monoexponential curve. Vagal stimulation or verapamil administration decreased the peak of the MRC and right-shifted the MRC. The postextrasystolic MRC was located upward compared with the control MRC, and was shifted downward by vagal stimulation or verapamil administration. If interventions having a negative inotropic effect effectively slow a rapid heart rate, the net effect of the ventricular contractile state may not always be negative. It was concluded that the MRC is useful in understanding LV contractility during irregular rhythm, especially when assessing the net effect of the negative dromotropic and inotropic action of antiarrhythmic drugs. (Jpn Circ J 1998; 62: 829 -836)

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Force-interval relationship in heart muscle of mammals. A calcium compartment model

Cited by 72 publications

References 47 publications

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.

Calcium metabolism and depressed contractility in isolated human and porcine heart muscle

Application of Mechanical Restitution

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