Force sensor probe using quartz crystal resonator with wide measurement range for mechanical characterization of HepG2 spheroid

Sakuma, Shinya; Sato, Ayaka; Kojima, Naoya; Tao, Fumiya; Arai, Fumihito

doi:10.1016/j.sna.2017.08.033

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…To enable the sensing of forces on the micronewton order, we fabricated a beam-shaped QCR force sensor, as shown in Fig. 8a 32 . The position of the QCR, corresponding to the sensing domain, is displaced from the neutral plane of the beam-shaped sensor (Fig.…”

Section: Methodsmentioning

confidence: 99%

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

et al. 2022

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To provide quantitative feedback on surgical progress to ophthalmologists practicing inner limiting membrane (ILM) peeling, we developed an artificial eye module comprising a quartz crystal resonator (QCR) force sensor and a strain body that serves as a uniform force transmitter beneath a retinal model. Although a sufficiently large initial force must be loaded onto the QCR force sensor assembly to achieve stable contact with the strain body, the highly sensitive and wide dynamic-range property of this sensor enables the eye module to detect the slight forceps contact force. A parallel-plate strain body is used to achieve a uniform force sensitivity over the 4-mm-diameter ILM peeling region. Combining these two components allowed for a measurable force range of 0.22 mN to 29.6 N with a sensitivity error within −11.3 to 4.2% over the ILM peeling area. Using this eye module, we measured the applied force during a simulation involving artificial ILM peeling by an untrained individual and compensated for the long-term drift of the obtained force data using a newly developed algorithm. The compensated force data clearly captured the characteristics of several types of motion sequences observed from video recordings of the eye bottom using an ophthalmological microscope. As a result, we succeeded in extracting feature values that can be potentially related to trainee skill level, such as the mean and standard deviation of the pushing and peeling forces, corresponding, in the case of an untrained operator, to 122.6 ± 95.2 and 20.4 ± 13.2 mN, respectively.

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Section: Methodsmentioning

confidence: 99%

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

et al. 2022

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“…While the elastic properties of biological systems have garnered substantial attention across various fields, the viscoelastic nature of multicellular systems remains minimally explored in literature [ 24 , 25 ]. Several experimental methodologies have been employed and customized for the investigation of these properties [ 26 ], including techniques such as atomic force microscopy (AFM) [ [27] , [28] , [29] , [30] ], indentation [ 28 ], tweezers [ 31 ], microfluidics [ [32] , [33] , [34] ], micropipettes [ 35 , 36 ], osmotic compression [ 37 ], and confocal-rheology [ 38 ]. These methodologies are characterized by sophisticated apparatus and necessitate technical skills that may not be readily available.…”

Section: Introductionmentioning

confidence: 99%

i-Rheo-optical assay: Measuring the viscoelastic properties of multicellular spheroids

Ferraro,

Guido,

Caserta

et al. 2024

Materials Today Bio

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“…Additionally, Sakuma et al created a cantilever-shaped QCR force sensor probe by building upon their previous work on force sensors. By utilizing this probe, high-resolution force sensing can be achieved [ 12 ]. In the past period, researchers have extensively studied the force-frequency characteristics of disc-type QCRs.…”

Section: Introductionmentioning

confidence: 99%

Study of Force-Frequency Characteristics in AT-Cut Strip Quartz Crystal Resonators with Different Rotation Angles

Yang

Huang

Tan

et al. 2023

Sensors

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This paper investigated the force-frequency characteristics of AT-cut strip quartz crystal resonator (QCR) employing finite element analysis methods and experiments. We used the finite element analysis software COMSOL Multiphysics to calculate the stress distribution and particle displacement of the QCR. Moreover, we analyzed the impact of these opposing forces on the frequency shift and strains of the QCR. Meanwhile, the resonant frequency shifts, conductance, and quality factor (Q value) of three AT-cut strip QCRs with rotation angles of 30°, 40°, and 50° under different force-applying positions were tested experimentally. The results showed that the frequency shifts of the QCRs were proportional to the magnitude of the force. The highest force sensitivity was QCR with a rotation angle of 30°, followed by 40°, and 50° was the lowest. And the distance of the force-applying position from the X-axis also affected the frequency shift, conductance, and Q value of the QCR. The results of this paper are instructive for understanding the force-frequency characteristics of strip QCRs with different rotation angles.

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Force sensor probe using quartz crystal resonator with wide measurement range for mechanical characterization of HepG2 spheroid

Cited by 10 publications

References 24 publications

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

i-Rheo-optical assay: Measuring the viscoelastic properties of multicellular spheroids

Study of Force-Frequency Characteristics in AT-Cut Strip Quartz Crystal Resonators with Different Rotation Angles

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