Force spectroscopy unveils hidden protein-folding states

Miller, Johanna L.

doi:10.1063/pt.3.3542

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…It allows for the imaging of biological objects from single molecules to the living cells as well as their manipulation. A lot of AFM modes have been developed to study biomolecules, and those modes are widely described in literature, but there is still a lot of research focused on improvements in AFM electronics, experiments with cantilever size [ 5 ], data interpretation and so on. This review is focused on the AFM capabilities to study protein biomolecules, their physicochemical properties, and perspectives to adapt AFM for biomedical detection of the low-abundance target proteins in solution.…”

Section: Introductionmentioning

confidence: 99%

Atomic Force Microscopy for Protein Detection and Their Physicoсhemical Characterization

Pleshakova

Bukharina

Archakov

et al. 2018

IJMS

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This review is focused on the atomic force microscopy (AFM) capabilities to study the properties of protein biomolecules and to detect the proteins in solution. The possibilities of application of a wide range of measuring techniques and modes for visualization of proteins, determination of their stoichiometric characteristics and physicochemical properties, are analyzed. Particular attention is paid to the use of AFM as a molecular detector for detection of proteins in solutions at low concentrations, and also for determination of functional properties of single biomolecules, including the activity of individual molecules of enzymes. Prospects for the development of AFM in combination with other methods for studying biomacromolecules are discussed.

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Section: Introductionmentioning

confidence: 99%

Atomic Force Microscopy for Protein Detection and Their Physicoсhemical Characterization

Pleshakova

Bukharina

Archakov

et al. 2018

IJMS

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Structurally Colored Photonic Crystal Biomimetic Microstructures for Daytime Radiative Cooling

Yang,

Wang,

Duan

et al. 2024

ACS Appl. Mater. Interfaces

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Daytime radiative cooling offers a novel solution to the energy crisis, enabling green and efficient thermal management in space. High reflectance in the solar spectrum is essential for passive radiative cooling, rendering dye coloring and similar methods unsuitable for colored coolers. This paper presents a structurally colored photonic crystal biomimetic microstructured radiative cooler. Inspired by natural biological systems, this cooler features a dual-layered microtruncated-cone array structure on the surface and bottom membrane layers. The silver reflector and 3D micrograting surface structure produce continuous iridescent colors through multiple interference effects. Optimized lithographic process enable the fabrication of the ordered dual-layer surface microstructure arrays with precise angular combinations. The dual-layered microtruncated-cone introduces a gradient refractive index, reducing impedance mismatch at the interface. As a result, the radiative cooler achieves high solar spectral reflectance (0.95) and high mid-infrared emissivity (0.95). Notably, the net theoretical cooling power and the subambient temperature drop are 106.9 W m −2 and 7.4 °C, respectively, at an ambient temperature of 40 °C, with a measured average temperature reduction of 6.1 °C under direct sunlight. This performance matches that of advanced radiative coolers, striking a balance between aesthetics and radiative cooling capability.

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Cryoelectron microscopy pioneers win chemistry Nobel

Miller¹

2017

Physics Today

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Force spectroscopy unveils hidden protein-folding states

Abstract: Specially developed short, bendy cantilevers may be the key to accessing biomolecular dynamics.

Cited by 3 publications

References 6 publications

Atomic Force Microscopy for Protein Detection and Their Physicoсhemical Characterization

Atomic Force Microscopy for Protein Detection and Their Physicoсhemical Characterization

Structurally Colored Photonic Crystal Biomimetic Microstructures for Daytime Radiative Cooling

Cryoelectron microscopy pioneers win chemistry Nobel

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