The study of flow, heat, and mass transfer of Newtonian and non-Newtonian nanofluid over porous media holds paramount significance in the context of fuel industries, contributing to enhanced efficiency, reduced emissions, and sustainable energy production. This investigation provides a concise overview of the critical role played by porous media in various aspects of the fuel sector. In the oil and gas industry, porous reservoir formations exhibit complex fluid dynamics characterized by non-Darcy flow, influencing recovery rates of hydrocarbons. Understanding the relationship between flow, heat, and mass transfer within these porous reservoirs is essential for reservoir engineers and fuels the quest for maximizing resource extraction. The Sisko nanofluid model is one of the most sought-after mathematical model which prophesies the interesting features of Newtonian and non-Newtonian (dilatant and Pseudoplastic nature) fluids. In contemporary years, a new class of non-Newtonian fluids with nanoparticle suspensions are gaining popularity as it is beneficial in enhancing thermal efficiency in several applications such as warming/cooling of home appliances and micro-electronics etc. However, the modeling on this class of non-Newtonian fluids is limited. In light of above, this work predicts the stream, heat and mass transmission behavior of nanofluids using Sisko fluid model. Stretching sheet with porous medium has been used for this study with addition with magnetic field, thermal radiation, Brownian motion and thermophoresis. The non-linearity issues in this fluid flow are addressed in the prevailing work using suitable similarity transformations. The non-linear dimensional coupled P.D.E are converted into nonlinear dimensionless coupled O.D.E. These equations are solved using MATLAB by implementing four-stage Lobatto IIIa formula. The impacts of copious physical parameters of flow, energy and mass transfer insights are discussed. From the outcomes of current work, it is perceived that increasing the perviousness of the porous medium reduces the fluid mobility. Further, for increased values of Prandtl number the heat transfer coefficient increases ensuing in more heat transfer. Flow, heat, and mass transfer over porous media are integral to fuel industries, influencing resource extraction, energy conversion, and product quality