“…The technique has been fairly widely applied to asthmatic subjects, some of whom retain helium-responsiveness while others do not (Despas et al, 1972;Benater, Clark & Cochrane, 1975). It has also been used to detect abnormalities in smokers with normal MEFV curves breathing air (Dosman et al, 1975) (Rosenblatt & Stein, 1962;Lal et al, 1964) which in subjects with airway disease is one of the least repeatable aspects of the spirogram.…”