Forced eye closure-induced reflex seizure and non-ketotic hyperglycemia

Tiras, Raziye; Mutlu, Aytül; Özben, Serkan; Aydemir, Tuba; Özer, Feriha

doi:10.4103/0256-4947.55319

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…[28][29][30] Cognitive seizures, such as aphasia, aphasic status epilepticus, and alexia; somatosensory seizures; 16,[31][32][33][34][35][36][37] and epilepsia partialis continua (EPC) [38][39][40] can also be observed. Thus, focal seizures that involve normal awareness or impaired awareness, and reflex seizures [41][42][43][44][45][46][47][48][49][50] can be caused by NKH.…”

Section: Irreversible Visual Loss (Table 4)mentioning

confidence: 99%

Epileptic manifestations, pathophysiology, and imaging characteristics of non-ketotic hyperglycaemia: a review of the literature and a report of two cases with irreversible cortical vision loss

Peddawad¹

2022

J Int Med Res

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The purpose of this review is to create more awareness regarding the epileptic manifestations of non-ketotic hyperglycaemia, which are not widely recognised, and to assist understanding of the pathophysiology involved. Given that type II diabetes is one of the common causes of morbidity worldwide, it is important to appreciate the various neurological manifestations of non-ketotic hyperglycaemia. Here, I present two cases and review the existing literature. Both patients developed irreversible vision loss, which is a novel finding because only transient visual defects have previously been reported. The review includes a detailed discussion of the pathophysiology and characteristic magnetic resonance imaging (MRI) findings of patients with defects in cerebral lobar regions, which were associated with a variety of clinical manifestations. These manifestations can be ascribed to epileptic phenomena involving various parts of the cerebrum. Hyperglycaemia can lead to the irreversible loss of vision. Early diagnosis and treatment on the basis of the clinical features and characteristic MRI findings are important to avoid an epilepsia partialis continua-like state and irreversible visual impairment.

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Section: Irreversible Visual Loss (Table 4)mentioning

confidence: 99%

Epileptic manifestations, pathophysiology, and imaging characteristics of non-ketotic hyperglycaemia: a review of the literature and a report of two cases with irreversible cortical vision loss

Peddawad¹

2022

J Int Med Res

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“…Epileptic seizures in diabetic patients are mostly reported as focal seizures (13,14,15,16,17,18,19) with or without secondary generalization; epilepsy partialis continua (EPC) (20,21,22,23,24,25,26,27,28), occipital seizures (29,30,31,32,33), and reflex seizures (34,35,36) have also been described. However, some cases of generalized epilepsy (childhood absence epilepsy, juvenile absence epilepsy, tonic-clonic seizures on wakening, and juvenile myoclonic epilepsy) associated with T1DM have also been reported (7,9,37,38).…”

Section: Introductionmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Seizures and type 1 diabetes mellitus: current state of knowledge

Verrotti

Scaparrotta

Olivieri

et al. 2012

European Journal of Endocrinology

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In this review, we will try to analyze the possible coexistence between epilepsy or seizures and type 1 diabetes mellitus (T1DM), in order to establish if there is more than a casual association, and to investigate possible mechanisms underlying this link. Anti-glutamic acid decarboxylase antibodies (GAD-Abs) have been associated with T1DM and a great number of neurological diseases such as epilepsy. Epilepsy can be a feature of a large variety of autoimmune or inflammatory disorders. GAD-Abs can have a role at the basis of the possible link between epilepsy and T1DM, although their real pathogenetic mechanism in neurological diseases is still unknown. Metabolic conditions such as hypoglycemia and hyperglycemia, common problems in diabetic patients, may be also implicated, even if their underlying mechanism is minimally understood.

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Diabetes and Epilepsy in Children and Adolescents

2015

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Over the last years, there has been an increasing interest in the potential association between type 1 diabetes (T1D) and epilepsy. Both T1D and epilepsy are common conditions in children and adolescents, and therefore, their association might represent simply a coincidence or be related to common underlying mechanisms with a potential causal relationship. Few epidemiological studies have been performed in the pediatric population, and they have reached discordant conclusions, with some studies reporting an increased prevalence of epilepsy in children and adolescents with T1D, whereas others have not confirmed this finding. Several mechanisms could explain the occurrence of epilepsy in young people with T1D, such as metabolic abnormalities (hypo/hyperglycemia) and autoantibodies, along with a genetic predisposition and the presence of brain lesions/damage. Further studies are required to better define whether there is a causal relationship between the two conditions and to understand the underlying mechanisms.

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Forced eye closure-induced reflex seizure and non-ketotic hyperglycemia

Cited by 4 publications

References 9 publications

Epileptic manifestations, pathophysiology, and imaging characteristics of non-ketotic hyperglycaemia: a review of the literature and a report of two cases with irreversible cortical vision loss

Epileptic manifestations, pathophysiology, and imaging characteristics of non-ketotic hyperglycaemia: a review of the literature and a report of two cases with irreversible cortical vision loss

MECHANISMS IN ENDOCRINOLOGY: Seizures and type 1 diabetes mellitus: current state of knowledge

Diabetes and Epilepsy in Children and Adolescents

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