Forearm bone mineral density in postmenopausal women with osteoarthritis of the knee

Iwamoto, Jun; Takeda, Tsuyoshi; Ichimura, Shoichi

doi:10.1007/s776-002-8408-y

Cited by 18 publications

(10 citation statements)

References 24 publications

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“…The loss of bone density, especially in post-menopausal women, is documented by many researchers (Burger et al, 1996;Hannan et al, 1993;Iwamoto et al, 2002;Jones et al, 1995;Nuti and Martini, 1993;Peterlik, 1997;Schneider et al, 2002). The deficiency of oestrogen observed with ageing is an important factor in the pathogenesis of bone fragility (Currey, 1969).…”

Section: Discussionmentioning

confidence: 96%

“…Indeed, in several studies (Hochberg et al, 2004;Iwamoto et al, 2002;Hulet et al, 2002;Schneider et al, 2002), patients with low bone density also had osteoarthritis. Dequeker et al (2003) interpreted this fact as an increased bone loss due to local disability in relation to the joint affected by osteoarthritis.…”

Section: Article In Pressmentioning

confidence: 97%

“…A few studies present a large age range (Hochberg et al, 1991(Hochberg et al, , 1994(Hochberg et al, , 2004 but many are limited to post-menopausal women (Bettica et al, 2002;Iwamoto et al, 2002;Schneider et al, 2002;Yahata et al, 2002;Del Puente et al, 2003) or elderly people (Marcelli et al, 1995;Nevitt et al, 1995;Burger et al, 1996). Generally, the samples were not randomized in the majority of the studies.…”

Section: Article In Pressmentioning

confidence: 99%

“…However, many studies proposed to measure bone mineral density in a peripheral bone site such as radius, metacarpal or phalanges (e.g. Hochberg et al, 1991Hochberg et al, , 1994Hochberg et al, , 1995Bischoff et al, 2000;Iwamoto et al, 2002;Yahata et al, 2002;Ohtsuka et al, 2002). Furthermore, the distance between osteoarthritis sites and sites of bone mineral density measurements varied between the studies.…”

Section: Article In Pressmentioning

confidence: 99%

“…Over the last several decades, the inverse association between osteoarthritis and osteoporosis has been demonstrated in many clinical studies (Belmonte-Serrano et al, 1993;Bettica et al, 2002;Bischoff et al, 2000;Burger et al, 1996;Del Puente et al, 2003;Dequeker et al, 2003;El Miedany et al, 2000;Hochberg et al, 2004;Iwamoto et al, 2002;Marcelli et al, 1995;Naganathan et al, 2002;Nevitt et al, 1995;Sowers et al, 1999;Yahata et al, 2002). Individuals with clinical and radiographic osteoarthritis present higher adjusted levels of bone mass than those without osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Are bone losers distinguishable from bone formers in a skeletal series? Implications for adult age at death assessment methods

Schmitt

Wapler

Couallier³

et al. 2007

HOMO

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Clinical studies indicate that genetic factors play a crucial role in primary osteoarthritis and osteoporosis. In addition, it has been suggested that these two diseases are inversely related. Within a population, one can find two sub-groups: the ''bone formers'' and the ''bone losers''. The changes to the joint surfaces used to assess adult age at death are related to the loss of bone substance and to bone formation (osteophytes). The modification of these indicators with age differs between bone formers and bone losers. Therefore, age-at-death assessment methods should make use of two standards, one for each sub-group. A preliminary study examining the possibility of distinguishing those who lose cortical bone from those who show signs of bony formation was conducted on a series of skeletons from Portugal, dating to the end of 19th century and the beginning of the 20th. Bone loss was evaluated using the cortical index (CI) of the second metacarpal on X-rays. The presence of osteophytes on dry bones was assessed macroscopically.Our study indicates that females' CI decreases with age, whereas the presence of osteophytes is strongly related to age in both sexes. But we have failed to find the inverse relationship Re´sumeD e nombreuses e´tudes de´montrent que les facteurs ge´ne´tiques jouent un roˆle crucial dans le de´veloppement de l'arthrose et de l'oste´oporose et que ces deux maladies sont inversement proportionnelles. En effet, au sein d'une meˆme population, deux groupes se distinguent: les )bone fomers* (ceux qui fabriquent de la substance osseuse) et les )bone losers* (ceux qui ont tendance a`la perdre). Or, les modifications des surfaces articulaires utilise´es pour estimer l'aˆge au de´ce`s des adultes sont lie´es a`la formation et a`la perte de substance osseuse. Par conse´quent, ces indicateurs e´voluent diffe´remment selon la cate´gorie a`laquelle l'individu appartient. Chaque me´thode devrait donc proposer deux standards diffe´rents. Pour tester cette hypothe`se, une e´tude pre´liminaire a e´te´mene´e sur une se´rie de squelettes portugais (fin du 19 ie`me /de´but du 20 ie`me sie`cle). Son objectif est de savoir s'il est possible de distinguer les )bone formers* des )bone losers*. La perte osseuse a e´te´e´value´e par l'index cortical du second me´tacarpien sur radiographies. La pre´sence d'oste´ophytes a e´te´diagnostique´e sur os sec. La relation inverse entre les oste´ophytes et la perte osseuse n'a pas e´te´de´montre´e. Par conse´quent, la tentative de distinguer les )bone losers* et les )bone formers* s'est re´ve´le´e infructueuse. Toutefois, notre e´tude indique que certains individus ne de´veloppent pas d'oste´ophytes.

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Section: Discussionmentioning

confidence: 96%

Section: Article In Pressmentioning

confidence: 97%

Section: Article In Pressmentioning

confidence: 99%

Section: Article In Pressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Are bone losers distinguishable from bone formers in a skeletal series? Implications for adult age at death assessment methods

Schmitt

Wapler

Couallier³

et al. 2007

HOMO

View full text Add to dashboard Cite

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Osteoarthritis and osteoporosis: Clinical and research evidence of inverse relationship

Dequeker¹,

Aerssens

Luyten³

2003

Aging Clin Exp Res

239

178

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The etiology of osteoporosis (OP) and osteoarthritis (OA) is multifactorial: both constitutional and environmental factors, ranging from genetic susceptibility, endocrine and metabolic status, to mechanical and traumatic injury, are thought to be involved. When interpreting research data, one must bear in mind that pathophysiologic factors, especially in disorders associated with aging, must be regarded as either primary or secondary. Therefore, findings in end-stage pathology are not necessarily the evidence or explanation of the primary cause or event in the diseased tissue. Both aspects of research are important for potentially curative or preventive measures. These considerations, in the case of our topic--the inverse relationship of OP and OA--are of particular importance. Although the inverse relationship between two frequent diseases associated with aging, OA and OP, has been observed and studied for more than 30 years, the topic remains controversial for some and stimulating for many. The anthropometric differences of patients suffering from OA compared with OP are well established. OA cases have stronger body build and are more obese. There is overwhelming evidence that OA cases have increased BMD or BMC at all sites. This increased BMD is related to high peak bone mass, as shown in mother-daughter and twin studies. With aging, the bone loss in OA is lower, except when measured near an affected joint (hand, hip, knee). The lower degree of bone loss with aging is explained by lower bone turnover as measured by bone resorption-formation parameters. OA cases not only have higher apparent and real bone density, but also wider geometrical measures of the skeleton, diameters of long bones and trabeculae, both contributing positively to better strength and fewer fragility fractures. Not only is bone quantity in OA different but also bone quality, compared with controls and OP cases, with increased content of growth factors such as IGF and TGFbeta, factors required for bone repair. Furthermore, in vitro studies of osteoblasts recruited from OA bone have different differentiation patterns and phenotypes. These general bone characteristics of OA bone may explain the inverse relationship OA-OP and why OA cases have fewer fragility fractures. The role of bone, in particular subchondral bone, in the pathophysiology, initiation and progression of OA is not fully elucidated and is still controversial. In 1970, it was hypothesized that an increased number of microfractures lead to an increase in subchondral bone stiffness, which impairs its ability to act as a shock absorber, so that cartilage suffers more. Although subchondral bone is slightly hypomineralized because of local increased turnover, the increase in trabecular number and volume compensates for this, resulting in a stiffer structure. There is also some experimental evidence that osteoblasts themselves release factors such as metalloproteinases directly or indirectly from the matrix, which predispose cartilage to deterioration. Instead, the osteoblast regener...

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Lower bone mineral density of forearm in postmenopausal patients with radiographic hand osteoarthritis

2009

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The association between clinical parameters and forearm bone mineral density (BMD) in postmenopausal females with radiographic hand OA has not been determined. We investigated the difference in forearm BMD between radiographic hand OA and non-radiographic hand OA, and also the association between clinical parameters of patients and the level of forearm BMD. A total of 180 postmenopausal patients with hand OA were enrolled in this study. We classified them into two groups according to the Kellgren-Lawrence (K-L) radiological grade, one with radiographic hand OA (K-L grade > or = 2) and the other with non-radiographic OA (K-L grade < 2) as controls. The number of nodal joints, swollen joints and tender joints were determined in the physical examination, and measures of BMD (g/cm(2)), Australian Canadian (AUSCAN) OA hand index, grip strength, pinch strength, and visual analogue scale (VAS) were also estimated. Patients with radiographic hand OA had lower distal radius BMD when compared with controls (0.35 +/- 0.06 vs. 0.40 +/- 0.05, P < 0.001). After adjusting for variables such as age, menopausal duration, number of nodal joints, and AUSCAN function index, the difference in BMD between the two groups was also significantly different (0.35 +/- 0.04 vs. 0.38 +/- 0.04, P < 0.001). For analysis of risk factors for forearm BMD in hand OA, age and K-L OA grade in total hand OA are considered risk factors, whereas age and menopause duration contribute to the forearm BMD in radiographic hand OA patients (P < 0.001, P = 0.002, respectively). The development of osteoporosis at the distal radius in radiographic hand OA is associated with older age (OR = 1.216, P = 0.002), lower BMI (OR = 0.777, P = 0.004) and lower stiffness in the AUSCAN OA index (OR = 0.505, P = 0.003). This study shows that the BMD levels of the distal radius in patients with radiographic hand OA are significantly lower when compared to those of controls. Forearm BMD levels are positively associated with age and K-L radiological grade in total hand OA, whereas age and menopausal duration are closely related with radiographic hand OA. The presence of osteoporosis in the distal radius in radiographic hand OA may be influenced by age, BMI, and stiffness on the AUSCAN index.

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Forearm bone mineral density in postmenopausal women with osteoarthritis of the knee

Cited by 18 publications

References 24 publications

Are bone losers distinguishable from bone formers in a skeletal series? Implications for adult age at death assessment methods

Are bone losers distinguishable from bone formers in a skeletal series? Implications for adult age at death assessment methods

Osteoarthritis and osteoporosis: Clinical and research evidence of inverse relationship

Lower bone mineral density of forearm in postmenopausal patients with radiographic hand osteoarthritis

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