Forebrain projections of the rostral nucleus raphe magnus shown by iontophoretic application of choleratoxin b in rats

Hermann, Dirk M.; Luppi, Pierre‐Hervé; Peyron, Christelle; Hinckel, P.; Jouvet, Michel

doi:10.1016/0304-3940(96)13013-5

Cited by 17 publications

(11 citation statements)

References 15 publications

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“…(Light-evoked changes in RVM activity could also modulate light -evoked responses in somatosensory pathways, e.g., trigeminal complex or thalamus.) Alternatively or in addition, the extensive ascending projections of the RVM to limbic forebrain 32,56–57 could play some role in producing light-induced aversion. Although the function of the ascending RVM projections has not been investigated, it is not unreasonable to think that they could contribute to the aversion resulting from ON-cell activation.…”

Section: Discussionmentioning

confidence: 99%

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A possible neural mechanism for photosensitivity in chronic pain

Martenson

Halawa

Tonsfeldt

et al. 2016

Pain

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Patients with functional pain disorders often complain of generalized sensory hypersensitivity, finding sounds, smells, or even everyday light aversive. The neural basis for this aversion is unknown, but cannot be attributed to a general increase in cortical sensory processing. Here we quantified the threshold for aversion to light in patients with fibromyalgia, a pain disorder thought to reflect dysregulation of brain pain-modulating systems. These individuals expressed discomfort at light levels substantially lower than healthy controls. Complementary studies in lightly anesthetized rat demonstrated that a subset of identified pain-modulating neurons in the rostral ventromedial medulla unexpectedly responds to light. Approximately half of the pain-facilitating “ON-cells” and pain-inhibiting “OFF-cells” sampled exhibited a change in firing with light exposure, shifting the system to a pro-nociceptive state with activation of ON-cells and suppression of OFF-cell firing. The change in neuronal firing did not require a trigeminal or posterior thalamic relay, but was blocked by inactivation of the olivary pretectal nucleus. Light exposure also resulted in a measurable but modest decrease in the threshold for heat-evoked paw withdrawal, as would be expected with engagement of this pain-modulating circuitry. These data demonstrate integration of information about light intensity with somatic input at the level of single pain-modulating neurons in the brainstem of the rat under basal conditions. Taken together, our findings in rodents and humans provide a novel mechanism for abnormal photosensitivity, and suggest that light has the potential to engage pain-modulating systems such that normally innocuous inputs are perceived as aversive or even painful.

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Section: Discussionmentioning

confidence: 99%

“…These findings add to the known inputs to the RVM that have the potential to modulate nociceptive responsiveness, including sensory inputs and top-down influences from higher centers such as periaqueductal gray, amygdala, and hypothalamus. 1,29,31–32,42–43,46,55–57 …”

Section: Discussionmentioning

confidence: 99%

A possible neural mechanism for photosensitivity in chronic pain

Martenson

Halawa

Tonsfeldt

et al. 2016

Pain

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“…VP exhibits serotonin transporter-IR (Sur et al, 1996) and the dorsal raphe (DR) projects to VP (Semba et al, 1988; Jones and Cuello, 1989; Vertes, 1991; Hermann et al, 1996). Post mortem VP tissue contains high concentrations of 5-HT and its metabolites (Napier and Potter, 1989), and 5-HT is detected in vivo using microdialysis in rats (Sizemore et al, 2000).…”

Section: 0 Afferent Inputs and Changes In Firing Rates Induced By mentioning

confidence: 99%

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Root

Meléndez

Záborszky

et al. 2015

Progress in Neurobiology

312

362

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The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psychiatric disorders. This review is presented to help bridge the gap by providing a resource for current knowledge of VP anatomy, projection patterns and subregional circuits, and how this organization relates to the function of VP neurons and ultimately behavior. For example, ventromedial (VPvm) and dorsolateral (VPdl) VP subregions receive projections from nucleus accumbens shell and core, respectively. Inhibitory GABAergic neurons of the VPvm project to mediodorsal thalamus, lateral hypothalamus, and ventral tegmental area, and this VP subregion helps discriminate the appropriate conditions to acquire natural rewards or drugs of abuse, consume preferred foods, and perform working memory tasks. GABAergic neurons of the VPdl project to subthalamic nucleus and substantia nigra pars reticulata, and this VP subregion is modulated by, and is necessary for, drug-seeking behavior. Additional circuits arise from nonGABAergic neuronal phenotypes that are likely to excite rather than inhibit their targets. These subregional and neuronal phenotypic circuits place the VP in a unique position to process motivationally-relevant stimuli and coherent adaptive behaviors.

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“…The brainstem raphe nuclei receive afferents from a large number of brain structures (Hermann et al, 1996, 1997). Significantly, these projections include inputs to the nucleus raphe magnus, nucleus raphe pallidus and the dorsal raphe from the prelimbic, infralimbic and precentral cortices, dorsal hypothalamic area, the midbrain periaqueductal gray, pre-optic area, bed nucleus of the stria terminalis, amygdala, parabrachial nucleus, Kolliker-Fuse and the subcoerulus area in the pons.…”

Section: 3 Afferent Inputs and Projections Of Serotonergic Neurons In The Brainmentioning

confidence: 99%

The role of serotonin in respiratory function and dysfunction

Hilaire¹,

Voituron²,

Menuet³

et al. 2010

Respiratory Physiology & Neurobiology

145

121

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Serotonin (5-HT) is a neuro-modulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre-and postnatal development of neural circuits. The functional implications of 5-HT is particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.

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Forebrain projections of the rostral nucleus raphe magnus shown by iontophoretic application of choleratoxin b in rats

Cited by 17 publications

References 15 publications

A possible neural mechanism for photosensitivity in chronic pain

A possible neural mechanism for photosensitivity in chronic pain

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

The role of serotonin in respiratory function and dysfunction

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