Combined heat and power (CHP) systems have been employed in various applications for years. They are gaining increasing attention in the residential and small industrial sectors for their primary energy saving potential and CO
2 emissions reduction. Additionally, in specific applications such as the hospital sector, CHP plants can play a critical role in replacing fossil-fueled electric generators to supply electricity during local grid outages, thus enhancing hospital facilities’ energy efficiency, while also securing reliability and efficiency of operation. Hospitals have unique energy demand profiles, with high and constant demand (particularly heating and cooling demands), making them an ideal use-case for trigeneration systems. Combined, cooling, heating and power plants (CCHP) are capable to provide not only heating and electricity, but also cooling through the efficient exploitation of a single energy source, reducing Hospitals’ reliance on the local grid. In this context, this work aims at evaluating the potential of a battery-integrated CCHP plant through an innovative ammonia-water absorption system, whose energy analysis is based on data acquired from an Italian Hospital facility. The potential of integrating an experimental combined cooling and power production ammonia-water absorption system has been investigated starting from an optimized battery energy storage system (BESS) CHP plant configuration, studied for the same facility. A proper control strategy has been developed to maximize the cooling production when required from the end-user through CHP plant’s exhaust gases waste heat recovery. The energy analysis demonstrated the advantages of the CCHP-BESS plant over the optimal CHP-BESS configuration, with an 11.22% increase in primary energy saving, a 9.85% reduction in CO
2 emissions, and a 5.03% decrease in electric peak power demand.