Machine learning has become an increasingly popular area of research in the field of education, with potential applications in various aspects of higher education curriculum design. This study aims to review the current applications of AI in the curriculum design of higher education. We conducted an initial search for articles on the application of machine learning in curriculum design in higher education. This involved searching three core educational databases, including the Educational Research Resources Information Centre (ERIC), the British Education Index (BEI), and Education Research Complete, to identify relevant literature. Subsequently, this study performed network analysis on the included literature to gain a deeper understanding of the common themes and topics within the field. The results showed a growing trend in publishing research on the application of machine learning within the educational domain. Our review pinpointed merely 11 publications specifically targeting the application of machine learning in higher education course design, with only three being peer-reviewed articles. Through the word cloud visualization, we discerned the most prominent keywords to be AI, foreign countries, pedagogy, online courses, e-learning, and course design. Collectively, these keywords underscore the significance of AI in molding the educational landscape, as well as the expanding tendency to incorporate AI technologies into online and technology-enhanced learning experiences. Although there is a significant amount of research on the application of machine learning in education, the literature on its specific use in higher education course design still needs to be expanded. Our review identified only a small number of studies that directly focused on this topic, and among them. The network analysis generated from the included literature highlights important themes related to student learning and performance and the use of models and algorithms. However, there is still a need for further research in this area to fully understand the potential of machine learning in higher education course design. This study would contribute literature in this specific field. The review can update teacher’s awareness of using machine learning in teaching practice. Additionally, it implies more and more researchers conduct related research in this area. Future studies should consider the limitations of the existing literature and explore new approaches to incorporate machine learning into curriculum design to improve student learning outcomes.