Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models

Akushevich, Igor; Yashkin, Arseniy; Kovtun, Mikhail; Kravchenko, Julia; Arbeev, Konstantin G.; Yashin, Anatoly I.

doi:10.1016/j.exger.2023.112133

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…These conditions have a profound impact on cognitive function, motor control, and overall quality of life, particularly in the elderly population. As individuals age, the incidence of both Alzheimer's and Parkinson's diseases increases, highlighting the significant burden these conditions pose on global health [188][189][190]. The pathogenesis of Alzheimer's and Parkinson's diseases involves a complex interplay of genetic, environmental, and lifestyle factors.…”

Section: Environmental Drivers Of Unhealthy Cerebrovascular and Brain...mentioning

confidence: 99%

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Pandics,

Major,

Fazekas-Pongor

et al. 2023

GeroScience

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The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer’s disease, Parkinson’s disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood–brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.

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Section: Environmental Drivers Of Unhealthy Cerebrovascular and Brain...mentioning

confidence: 99%

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Pandics,

Major,

Fazekas-Pongor

et al. 2023

GeroScience

View full text Add to dashboard Cite

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“…Recent estimates place the prevalence of AD in U.S. older adults age 65+, at about 11,300 per 100,000 [15,16]; although more prevalent in females [17,18] the role of biological sex in AD risk is not straightforward [19]. In the future, AD is expected to exhibit rising incidence and post-onset mortality coupled with falling survival [20] leading to a projected increase in the prevalence of AD in the U.S [16,21,22]. Graves disease (GD) is an autoimmune disorder that causes overproduction of thyroid hormones which can accelerate the metabolism, leading to a weight loss, rapid heartbeat, and other symptoms; GD is the most common cause of hyperthyroidism in the U.S [23].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Graves disease is associated with increased risk of clinical Alzheimer’s disease: evidence from the Medicare system

Yashkin,

Kolpakov,

Ukraintseva

et al. 2024

Clin Diabetes Endocrinol

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Background Identification of modifiable risk factors for Alzheimer’s Disease (AD) onset is an important aspect of controlling the burden imposed by this disease on an increasing number of older U.S. adults. Graves disease (GD), the most common cause of hyperthyroidism in the U.S., has been hypothesized to be associated with increased AD risk, but there is no consensus. In this study, we explore the link between GD and risk of clinical AD. Methods Cox and Fine-Grey models were applied to a retrospective propensity-score-matched cohort of 19,798 individuals with GD drawn from a nationally representative 5% sample of U.S. Medicare beneficiaries age 65 + over the 1991–2020 period. Results Results showed that the presence of GD was associated with a higher risk of AD (Hazard Ratio [HR]:1.19; 95% Confidence Interval [CI]:1.13–1.26). Competing risk estimates were consistent with these findings (HR:1.14; CI:1.08–1.20) with the magnitude of associated risk varying across subgroups: Male (HR:1.25; CI:1.07–1.47), Female (HR:1.09; CI:1.02–1.16), White (HR:1.11; CI:1.03–1.19), and Black (HR:1.23; CI:1.02–1.49). Conclusions Our results indicate a robust and consistent association between a diagnosis of GD and a subsequent diagnosis of AD in later stages of life. The precise biological pathways that could potentially connect these two conditions remain unclear as is the role of treatment in this relationship. Replications of these findings on datasets with both biomarkers and laboratory test results, especially in underrepresented groups is vital.

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“…Epidemiological studies have shed light on the prevalence and impact of cognitive decline and dementia across the aging populations of the developed world [10][11][12][13]. Alzheimer's disease and other neurodegenerative disorders have received considerable attention due to their devastating effects on memory, cognition, and daily functioning [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

Ungvari,

Gulej,

Csik

et al. 2023

Nutrients

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As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of methionine-rich foods such as red meat. The present review delves into the impact of this methionine-heavy diet and the resultant hyperhomocysteinemia on accelerated cerebrovascular and brain aging, emphasizing their potential roles in cognitive impairment. Through a comprehensive exploration of existing evidence, a link between high methionine intake and hyperhomocysteinemia and oxidative stress, mitochondrial dysfunction, inflammation, and accelerated epigenetic aging is drawn. Moreover, the microvascular determinants of cognitive deterioration, including endothelial dysfunction, reduced cerebral blood flow, microvascular rarefaction, impaired neurovascular coupling, and blood–brain barrier (BBB) disruption, are explored. The mechanisms by which excessive methionine consumption and hyperhomocysteinemia might drive cerebromicrovascular and brain aging processes are elucidated. By presenting an intricate understanding of the relationships among methionine-rich diets, hyperhomocysteinemia, cerebrovascular and brain aging, and cognitive impairment, avenues for future research and potential therapeutic interventions are suggested.

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Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models

Cited by 4 publications

References 54 publications

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Graves disease is associated with increased risk of clinical Alzheimer’s disease: evidence from the Medicare system

The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

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