Forecasting the future burden of opioids for osteoarthritis

Ackerman, Ilana N.; Zomer, Ella; Gilmartin‐Thomas, Julia; Liew, Danny

doi:10.1016/j.joca.2017.11.001

Cited by 36 publications

(36 citation statements)

References 25 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, oxycodone is increasingly being prescribed for patients with OA according to the present study. This is in agreement with other studies, which also found increases in the prescription rate of oxycodone for OA [ 12 ] and strong opioids for musculoskeletal pain in general [ 21 ]. At the same time as the prescription rates for oxycodone and fentanyl increased, the prescription rates for paracetamol/codeine and tramadol/paracetamol decreased.…”

Section: Discussionsupporting

confidence: 93%

“…Most of the studies examining opioid prescriptions in OA patients found an increase in the prescription rate [ 12–14 , 19 ] while we found a relatively stable prescription rate. One study looking at US insurance data claims also found a relatively stable opioid prescription rate [ 20 ].…”

Section: Discussioncontrasting

confidence: 38%

“…Despite the questionable benefit and the frequency of side effects, the use of opioids in OA patients is high [ 11 , 12 ] and increasing [ 13 , 14 ]. Earlier research examined the total use of opioids for OA, but did not focus on which types of opioids were used [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Opioid prescriptions in patients with osteoarthritis: a population-based cohort study

et al. 2020

View full text Add to dashboard Cite

Objectives To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated with the prescription of opioids were assessed. Methods A population-based cohort study was conducted using the Integrated Primary Care Information database. Incidence and prevalence of opioid prescriptions were calculated for the period 2008–2017. Logistic regression was used to assess which patient characteristics were associated with opioid prescriptions. Results In total, 157 904 OA patients were included. The overall prescription rate remained fairly stable, at around 100 incident and 170 prevalent prescriptions per 1000 person years. However, the incident prescription rate for oxycodone increased from 7.1 to 40.7 per 1000 person years and for fentanyl from 4.2 to 7.4 per 1000 person years. The incident prescription rate for paracetamol/codeine decreased from 63.0 to 13.3 per 1000 person years. Per follow-up year, long-term use was found in 3% of the patients with incident OA. Finally, factors associated with more prescriptions were increasing age, OA in ≥2 joint groups [odds ratio (OR) 1.56; 95% CI: 1.51, 1.65] and the presence of other musculoskeletal disorders (OR 4.91; 95% CI: 4.76, 5.05). Men were less likely to be prescribed opioids (OR 0.78; 95% CI: 0.76, 0.80). Conclusion Prescription rates for opioids remained stable, but types of opioids prescribed changed. Oxycodone and fentanyl were increasingly prescribed, while prescriptions of paracetamol/codeine decreased. Since the benefit of opioids for OA pain is questionable and side effects are common, opioids should be prescribed with caution.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 38%

See 1 more Smart Citation

Opioid prescriptions in patients with osteoarthritis: a population-based cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The development of effective therapeutics for optimal pain management has lagged behind other areas, such as inflammation control and the regulation of autoimmunity, which is partially responsible for the current epidemic of opioid and narcotic abuse. A recent report showed that nearly 10% of all opioids prescribed in Australian general practice are prescribed for OA [4]. Similarly, in a survey of Swedish residents aged ≥35 years, 12% of incident opioid dispensations were attributable to OA and/or its related comorbidities [5].…”

Section: Introductionmentioning

confidence: 99%

“…Although there is inconclusive evidence for the benefits of opioids for arthritides and increasing awareness of the risks, opioid prescription rates for OA in the USA remained stable between 2007 and 2014 [6]. On the other hand, despite recent advances in the treatment of RA utilizing effective immunosuppressive therapies based on a better understanding of its underlying mechanism, remaining pain affected almost one third of early RA patients with a good clinical response [4]. By 2014, 41% of patients with RA in the USA were regular users of opioids [7].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models

Hong

Park

Kim

2020

IJMS

View full text Add to dashboard Cite

Arthritis, including osteoarthritis (OA) and rheumatoid arthritis (RA), is the leading cause of years lived with disability (YLD) worldwide. Although pain is the cardinal symptom of arthritis, which is directly related to function and quality of life, the elucidation of the mechanism underlying the pathogenesis of pain in arthritis has lagged behind other areas, such as inflammation control and regulation of autoimmunity. The lack of therapeutics for optimal pain management is partially responsible for the current epidemic of opioid and narcotic abuse. Recent advances in animal experimentation and molecular biology have led to significant progress in our understanding of arthritis pain. Despite the inherent problems in the extrapolation of data gained from animal pain studies to arthritis in human patients, the critical assessment of molecular mediators and translational studies would help to define the relevance of novel therapeutic targets for the treatment of arthritis pain. This review discusses biological and molecular mechanisms underlying the pathogenesis of arthritis pain determined in animal models of OA and RA, along with the methodologies used.

show abstract

Exploring views of orthopaedic surgeons, rheumatologists and general practitioners about osteoarthritis management

Wallis

Barton

Brusco

et al. 2021

Musculoskeletal Care

View full text Add to dashboard Cite

Background: Delivery of recommended treatments for hip and knee osteoarthritis (OA) is known to be discordant with guideline recommendations. However, professional views related to OA management across medical and surgical disciplines are not well understood. The aim of this study was to explore the views of medical professionals about management of hip and knee OA.Methods: Qualitative study. Semistructured individual interviews were conducted with orthopaedic surgeons, rheumatologists and general practitioners routinely involved in the management of OA. Interviews were audiotaped, transcribed, member-checked, coded and thematically analysed.Results: Fifteen medical professionals were interviewed. Three main themes were:(i) recognition of the importance of nonsurgical management of hip and knee OA, focussed on self-management, exercise-therapy, weight management and analgesia;(ii) joint replacement being considered the 'last resort' for end stage disease not responding to nonsurgical management; and (iii) determination of management 'success' through patient perceptions was more common than the use of validated instruments. Views on management broadly converged across disciplines, except for the role of joint replacement, considered an adjunct in the overall management of OA by rheumatologists and as a definitive cure by orthopaedic surgeons. Conclusions:Aligning with current guidelines, medical professionals recognised the importance of nonsurgical management focussed on exercise-therapy for hip and knee OA, and concurred that joint replacement surgery should be a last resort. A focus on patient education was less prominent, which along with implementation of validated outcome measures in routine medical practice, may require greater health system support.

show abstract

Forecasting the future burden of opioids for osteoarthritis

Cited by 36 publications

References 25 publications

Opioid prescriptions in patients with osteoarthritis: a population-based cohort study

Opioid prescriptions in patients with osteoarthritis: a population-based cohort study

Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models

Exploring views of orthopaedic surgeons, rheumatologists and general practitioners about osteoarthritis management

Contact Info

Product

Resources

About