In the context of urban planning, the design of urban spaces is recognized as a pivotal factor influencing urban sustainability, with a particular emphasis on inclusivity for individuals requiring special assistance. This study explores the interconnectedness of urban design with sustainability indicators, focusing on human-centric dimensions and the preservation of heritage within Najaf's traditional urban fabric. Through the application of Structural Equation Modeling (SEM) via the Analysis of Moment Structures (AMOS) software, this research aims to elucidate the significance and interrelations of specific urban design indicators, thereby determining their collective impact on urban sustainability. The methodology adopted herein leverages quantitative analysis to delineate the relationships among urban design parameters and their consequential influence on sustainability outcomes. The findings suggest a substantial correlation between urban design practices and the attainment of sustainability, with a notable emphasis on the design factor as a primary influencer. This research contributes to the discourse on urban sustainability by providing a methodological framework for assessing the role of urban design in fostering inclusive and sustainable urban environments. The study underscores the potential of SEM in elucidating the complex dynamics between urban design and sustainability, thereby offering empirical evidence to support the development of informed urban planning strategies.