Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series

Kavvadias, Tilemachos; Kaemmer, Daniel; Klinge, U.; Kuschel, Stefanie; Schuessler, Bernhard

doi:10.1007/s00192-009-0974-y

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…For this purpose, it was proved the fact that polypropylene integrates very well in human tissues, producing reduced reactions of rejection or of inflammations due to foreign body. [6,7] Certain studies proved the fact that, after introducing the polypropylene prosthesis within the human organism, on the abdominal wall, at the level of the place of implantation an initial local inflammation with a reduced fibroblastic reaction is produced, and in time a resistant scar is produced [8]. It was also demonstrated the fact that, compared to other heterologous materials placed at the level of the human tissue, the inflammatory reaction induced by polypropylene is considerably reduced [9,10].…”

Section: Resultsmentioning

confidence: 99%

Using Polypropylene for Bronchial Stump Closure After Pulmonary Resections

Suciu¹,

Hălmaciu²,

Bud³

et al. 2017

Mat.Plast.

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The bronchial stump fistula shown by patients undergoing adjusted pulmonary resections is an extremely severe condition affecting the prognosis of this patients. Within our study, we have used an innovative technique of closing the bronchial stump for 38 patients undergoing adjusted pulmonary resections. The suture of the bronchial stump was made through an innovative method, by practicing the suture with isolated 2.0 Prolene wires armed with patches of Polypropylene. The incidence of the bronchial stump fistula for the observed lot was of 5.26% (2 cases), smaller than the one reported in the specialty literature. In this respect, we consider that the use of Polypropylene in the techniques of closing the bronchial blunt can be beneficial.

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Section: Resultsmentioning

confidence: 99%

Using Polypropylene for Bronchial Stump Closure After Pulmonary Resections

Suciu¹,

Hălmaciu²,

Bud³

et al. 2017

Mat.Plast.

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“…Maybe, it already is the strain applied during placement that is responsible for the doubling of the textile, which can frequently be seen when investigating explanted meshes histologically. 19,20 The relevance of structural stability of course has to be defined by further studies, but there is a undisputable need for the adoption of the textile characteristic of pelvic floor implants to the special requirements of application and technique, not necessarily following the tension free conditions of hernia surgery. However, the present study offers a first characterization of textile pelvic floor implants under unixial mechanical stress, which may allow a better relation to clinical results as standard testing of effective porosity without any tension can do, 17 and in future might help to improve devices for this specific surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates

Otto

Kaldenhoff

Kirschner‐Hermanns

et al. 2013

J Biomedical Materials Res

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Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices has to include the impact of strain on stretchability and effective porosity. Prolift V R and Prolift 1 M V R , developed for tension free conditions, were tested by measuring stretchability and effective porosity applying mechanical strain. For comparison, we used Dynamesh-PR4 V R , which was designed for pelvic floor repair to withstand mechanical strain. Prolift V R at rest showed moderate porosity with little stretchability but complete loss of effective porosity at strain of 4.9 N/cm. Prolift 1 M V R revealed an increased porosity at rest, but at strain showed high stretchability, with subsequent loss of effective porosity at strain of 2.5 N/cm. Dynamesh PR4 V R preserved its high porosity even under strain, but as consequence of limited stretchability. Though in tension free conditions Prolift V R and Prolift 1 M V R can be considered as large pore class I meshes, application of mechanical strain rapidly lead to collapse of pores. The loss of porosity at mechanical stress can be prevented by constructions with high structural stability. Assessment of porosity under strain was found helpful to define requirements for pelvic floor devices. Clinical studies have to prove whether devices with high porosity as well as high structural stability can improve the patients' outcome.

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“…Our project went one step further and proved that the architectural features of polypropylene meshes have no impact on histological tissue responses in a 1-year period. The nature and intensity of inflammatory reactions may be critical for acceptance or rejection, and could subsequently influence mechanical properties as well as sling efficacy [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions

Przydacz

Adli

Mahfouz

et al. 2017

CEJU

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IntroductionTo evaluate the impact of design features of the synthetic mid-urethral slings on tissue integrity and inflammatory responses.Material and methodsIn total 30 female Sprague-Dawley rats were implanted with type I monofilamentous, macroporous polypropylene meshes: Gynecare TVT-Obturator tape® (Ethicon Inc., Johnson & Johnson, Somerville, NJ, USA) and I-STOP® (CL Medical Inc., Lyon, France). All animal groups were sacrificed at set time intervals – 6 weeks, 3 months, 6 months, 9 months and 12 months – and the abdominal wall was harvested with mesh strips for histological evaluation.ResultsAll mesh strips appeared to be well incorporated into the abdominal wall, and no signs of shrinkage was noticed. All specimens showed a thin/delicate, loose, fibrous interface between the synthetic graft plate and abdominal wall, along with mild inflammatory reactions from 6 weeks to 12 months.ConclusionsBoth mesh brands induced comparable, minimal foreign body reactions and integrated well into the host tissues despite differences in architectural features. TVT-O® and I-STOP® evoked similar low-grade inflammatory responses up to 12 months in this animal model.Structural differences and architectural features of polypropylene slings used in this study have had no impact on tissue integrity and inflammatory responses.

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Foreign body reaction in vaginally eroded and noneroded polypropylene suburethral slings in the female: a case series

Cited by 10 publications

References 13 publications

Using Polypropylene for Bronchial Stump Closure After Pulmonary Resections

Using Polypropylene for Bronchial Stump Closure After Pulmonary Resections

Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates

Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions

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