Foreign-body reaction to bone wax

Aurelio, James A.; Chenail, Bruce L.; Gerstein, Harold

doi:10.1016/0030-4220(84)90371-2

Cited by 37 publications

(18 citation statements)

References 3 publications

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“…[1][2][3][4][5][6][7][8] Localized pain, warmth, swelling, edema, and tenderness are the main clinical symptoms. [9][10][11] To our knowledge, this is the first report of bone wax-induced osteohypertrophy that caused exophthalmos 9 years after the first neurosurgery.…”

Section: Discussionmentioning

confidence: 99%

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Skull osteohypertrophy as a complication of bone wax

Kamide

Nakada

Hirota

et al. 2009

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

“…Bone wax-induced osteohypertrophy has not been reported to our knowledge, although other adverse effects are known. [1][2][3][4][5][6][7][8] …”

Section: Introductionmentioning

confidence: 99%

Skull osteohypertrophy as a complication of bone wax

Kamide

Nakada

Hirota

et al. 2009

Journal of Clinical Neuroscience

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“…The infection rate associated with such retained catheters is very low, probably because most retained catheters have migrated from the ventricular space into cortical tissue and remain in a sterile environment. Bone wax (beeswax, paraffin and isopropyl palmitate) is considered to be relatively innocuous, but a foreign body reaction (chronic granuloma with giant cell response) to bone wax has been described in a few clinical cases [11, 12]. Experimental animal models studies have suggested that bone wax delayed the clearance of bacteria and promoted infection [13].…”

Section: Discussionmentioning

confidence: 99%

Multiple Recurrent Gram-Negative Cerebrospinal Fluid Shunt Infections Associated with a Patient with a Retained Ventricular Foreign Body

Shingadia

Grant²,

Bendet³

et al. 1999

Pediatr Neurosurg

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A 3-year-old boy experienced 10 recurrent gram-negative ventriculoperitoneal shunt (VPS) infections with identical strains over a 17-month period. Multiple cranial MRI and CT scans to identify a retained foreign body were negative. CT myelography and pressure infusion radionuclide cisternography were also unhelpful. Ventriculoscopy revealed a small retained foreign body which was successfully removed, and cultures subsequently yielded gram-negative organisms identical to the previously identified bacteria by pulsed field gel electrophoresis. No further infections were noted after removal of the retained fragment. Exploratory ventriculostomy should be considered in patients with recurrent VPS infections where other techniques fail to reveal a cause.

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“…Wax is not resorbed by the adjacent bone or local surrounding tissues, and it causes chronic inflammation. [5][6][7] Furthermore, bone wax is a mechanical barrier to bone regeneration, [8][9][10][11] it lowers the bacterial clearance in cancellous bone, 12 and it can embolize. 13 Concerns over these undesirable properties of bone wax prompted research into the development of alternative hemostatics.…”

Section: Introductionmentioning

confidence: 99%

Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax

Orgill

Ehret

Regan

et al. 1998

J. Biomed. Mater. Res.

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Although bone wax is effective at achieving hemostasis, it is nonresorbable, causes a foreign body reaction, and inhibits osteogenesis. We report development of a polyethylene glycol/microfibrillar collagen composite (PEG/MFC) that has inherent hemostatic qualities, is biodegradable, and is compatible with bone repair. PEG/MFC composite (n = 42) was placed in 5 mm cranial defects in New Zealand white rabbits. Hemostasis and healing were compared to unfilled defects (n = 32) and defects filled with standard bone wax (n = 10). Both PEG/MFC and bone wax handled well and stopped bleeding. The polyethylene glycol component was resorbed by 8 h, and the microfibrillar collagen was resorbed over 2 months, eliciting only a minor inflammatory response during the first month. Defects filled with the PEG/MFC composite showed similar amounts of bony regeneration as did unfilled control defects. At 4 weeks, healing bone accounted for 43 +/- 13% in those treated with PEG/MFC and 47 +/- 19% defect area in untreated holes. In contrast, less than 1% of the area was bone in defects filled with bone wax (p < 0.05). PEG/MFC composite provided excellent bony hemostasis and did not inhibit bone growth.

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Foreign-body reaction to bone wax

Cited by 37 publications

References 3 publications

Skull osteohypertrophy as a complication of bone wax

Skull osteohypertrophy as a complication of bone wax

Multiple Recurrent Gram-Negative Cerebrospinal Fluid Shunt Infections Associated with a Patient with a Retained Ventricular Foreign Body

Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax

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