2014
DOI: 10.1016/j.brainres.2014.07.022
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Forelimb amputation-induced reorganization in the ventral posterior lateral nucleus (VPL) provides a substrate for large-scale cortical reorganization in rat forepaw barrel subfield (FBS)

Abstract: In this study, we examined the role of the ventral posterior lateral nucleus (VPL) as a possible substrate for large-scale cortical reorganization in the forepaw barrel subfield (FBS) of primary somatosensory cortex (SI) that follows forelimb amputation. Previously, we reported that, 6 weeks after forelimb amputation in young adult rats, new input from the shoulder becomes expressed throughout the FBS that quite likely has a subcortical origin. Subsequent examination of the cuneate nucleus (CN) 1 to 30 weeks f… Show more

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Cited by 21 publications
(20 citation statements)
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“…The lack of labeled neurons in abnormal locations in the VPM provides direct evidence that an anatomical reorganization of thalamocortical projections does not always play a significant role in mediating cortical reactivation after DCLs. Of course it is possible that the preserved thalamocortical connections may bring in reorganized inputs from the cuneate nucleus, as described in rodents (Li et al, 2014) and monkeys (Jain et al, 2000;present results). However, we observed a more widespread labeling in the representations of digits 3-4 in the VPL in monkey SM-Y (65% DCL) after a digit 2 injection in area 3b, suggesting that the thalamocortical projections may sprout and not completely conform to the normal, somatotopically matched pattern after injuries.…”
Section: Areas Pv/s2 and Other Cortical Areas In Lateral Sulcusmentioning
confidence: 78%
See 1 more Smart Citation
“…The lack of labeled neurons in abnormal locations in the VPM provides direct evidence that an anatomical reorganization of thalamocortical projections does not always play a significant role in mediating cortical reactivation after DCLs. Of course it is possible that the preserved thalamocortical connections may bring in reorganized inputs from the cuneate nucleus, as described in rodents (Li et al, 2014) and monkeys (Jain et al, 2000;present results). However, we observed a more widespread labeling in the representations of digits 3-4 in the VPL in monkey SM-Y (65% DCL) after a digit 2 injection in area 3b, suggesting that the thalamocortical projections may sprout and not completely conform to the normal, somatotopically matched pattern after injuries.…”
Section: Areas Pv/s2 and Other Cortical Areas In Lateral Sulcusmentioning
confidence: 78%
“…Distributions of CTB and BDA label were plotted and compared with somatotopic maps in areas 3b and 1. To reveal whether DCLs resulted in alteration of connection patterns in the thalamus (Li et al, ) and brainstem (Jain et al, ; Kambi et al, ; Li et al, ), we examined how CTB and BDA injections in area 3b labeled neurons in the VP and how B‐HRP injections in the skin of the anterior chin labeled axonal terminals in the brainstem. In each subsection, we describe results from four monkeys in an order based on the severity of DCLs.…”
Section: Resultsmentioning
confidence: 99%
“…These changes result in enhanced excitability of the deafferented SI cortex, as demonstrated in patients with PLP by Larbig et al 89 and Karl et al 78 . Also, the deafferented cortex gradually becomes responsive to stimulation of previously ineffective body regions 98,130,131,132 .…”
Section: Development Of Clinical Pain Conditionsmentioning
confidence: 99%
“…Patients with spinal cord injury often experience PLP and PLS (39). In a rodent model, forelimb amputation resulted in reorganization in both deafferented primary somatosensory cortex and the ventral posterior nucleus of the thalamus, the latter of which relayed the new input to the deafferented cortex (40). This finding lends further credence to a thalamic contribution to cortical reorganization.…”
Section: Subcortical Theories: Thalamic Contributionsmentioning
confidence: 77%