Forensic NMR metabolomics: one more arrow in the quiver

Locci, Emanuela; Bazzano, Giovanni; Chighine, Alberto; Locco, Francesco; Ferraro, Ernesto; Demontis, Roberto; d’Aloja, Ernesto

doi:10.1007/s11306-020-01743-6

Cited by 27 publications

(20 citation statements)

References 73 publications

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“…Omics sciences, following their large application in clinical medicine [16] are increasingly used in the forensic setting [17][18][19]. Recently, our research group reviewed previous, current and future potential applications of NMR metabolomics in the forensic field [20], while several works deal with metabolomics in perinatal asphyxia, in human and animal models [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Infant urinary metabolomic profile in a fatal acute methadone intoxication

et al. 2022

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A case report suspicious for a Sudden Infant Death Syndrome is here described. Pathological findings were consistent with an acute respiratory failure while toxicological analysis revealed an elevated blood methadone concentration. Death was then ascribed to an acute methadone intoxication. In addition to the routinary approach, the urinary sample collected at autopsy was investigated with a 1H NMR metabolomic approach and the identified metabolomic profile was challenged with the urinary metabolomic profiles previously obtained from 10 newborns who experienced perinatal asphyxia and 16 healthy control newborns. Intriguingly, the urinary profile of the methadone intoxicated infant was very similar to those belonging to the perinatal asphyxia newborns, especially to those belonging to the newborns characterised by the worst outcome. The results offer several hints on a shared metabolic derangement between different mechanisms of asphyxia/hypoxia. To the best of the authors’ knowledge, this is the first report of the use of a metabolomic approach in a pathological case, in which metabolomics offers useful additional information regarding the mechanism and the cause of death.

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Section: Discussionmentioning

confidence: 99%

Infant urinary metabolomic profile in a fatal acute methadone intoxication

et al. 2022

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“…What could be a significant limitation while using 1 H NMR is the availability of well-collected research material, sampled in a sufficient volume/quantity. In addition, another disadvantage is the availability of NMR equipment, which is not so widespread due to the huge price of the instruments [16].…”

Section: Methods Used In Forensic Instrumental Analysismentioning

confidence: 99%

“…By expanding the number of small molecules that might be identified and quantified in an analyzed biological sample, the pharmacokinetics, pharmacodynamics, and the mechanisms regularly occurring in the organism after taking a prescribed medication or consuming ethyl alcohol can be verified. Toxicogenetics is considered to have crucial significance in forensic examinations and may provide valuable information about genotypes, phenotypes, and possible specific alterations [14][15][16].…”

Section: Thanatometabolomicsmentioning

confidence: 99%

The Application of Metabolomics in Forensic Science with Focus on Forensic Toxicology and Time-of-Death Estimation

et al. 2021

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Recently, the diagnostic methods used by scientists in forensic examinations have enormously expanded. Metabolomics provides an important contribution to analytical method development. The main purpose of this review was to investigate and summarize the most recent applications of metabolomics in forensic science. The primary research method was an extensive review of available international literature in PubMed. The keywords “forensic” and “metabolomics” were used as search criteria for the PubMed database scan. Most authors emphasized the analysis of different biological sample types using chromatography methods. The presented review is a summary of recently published implementations of metabolomics in forensic science and types of biological material used and techniques applied. Possible opportunities for valuable metabolomics’ applications are discussed to emphasize the essential necessities resulting in numerous nontargeted metabolomics’ assays.

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“…Thus, there has been an increase in the quality of information obtained via instrumental analysis. NMR has been widely used owing to its high reproducibility and non-destructive nature [ 45 , 46 ]. However, this technique shows a relatively low sensitivity; hence, it requires samples with concentrations in the millimolar range for the collected data to be of significance.…”

Section: Application Of Metabolomics In the Study Of Biological Responses To Environmental Toxicantsmentioning

confidence: 99%

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Kim

Kang

2021

Metabolites

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Environmental pollution causes significant toxicity to ecosystems. Thus, acquiring a deeper understanding of the concentration of environmental pollutants in ecosystems and, clarifying their potential toxicities is of great significance. Environmental metabolomics is a powerful technique in investigating the effects of pollutants on living organisms in the environment. In this review, we cover the different aspects of the environmental metabolomics approach, which allows the acquisition of reliable data. A step-by-step procedure from sample preparation to data interpretation is also discussed. Additionally, other factors, including model organisms and various types of emerging environmental toxicants are discussed. Moreover, we cover the considerations for successful environmental metabolomics as well as the identification of toxic effects based on data interpretation in combination with phenotype assays. Finally, the effects induced by various types of environmental toxicants in model organisms based on the application of environmental metabolomics are also discussed.

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Forensic NMR metabolomics: one more arrow in the quiver

Cited by 27 publications

References 73 publications

Infant urinary metabolomic profile in a fatal acute methadone intoxication

Infant urinary metabolomic profile in a fatal acute methadone intoxication

The Application of Metabolomics in Forensic Science with Focus on Forensic Toxicology and Time-of-Death Estimation

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

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