Forensic science

Brettell, T. A.; Saferstein, R.

doi:10.1021/ac00060a015

Cited by 11 publications

(7 citation statements)

References 367 publications

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“…Though novel training [4] and funding initiatives [5] have helped to contend with the demand, forensic biology has proven to be indispensable for suspect identification, leading to a significant level of outsourcing to private labs [6,7]. While the development of higher performance analytical methods is seen as a means of accommodating the increasing number of these requests [8,9], so too are techniques that reduce the impact of other types of forensic evidence [5,10], allowing the reallocation of resources towards the more laborious biological analyses.…”

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

“…While established laboratory-based methods for drug investigation (e.g., hyphenated mass spectrometric (MS), spectroscopy, etc.) are known for their accuracy, broad applicability, and court admissibility [8,11,12], throughput is hindered by the required preparative steps and overall duty cycle. Ambient MS techniques [13,14], which increase sample throughput by forgoing extensive sample preparations, have shown proficiency in forensic chemical analysis [15][16][17], with recent reports involving the analysis of biofluids [18,19], explosives [20], adulterated foodstuffs [21], mind-altering plant-based evidence [22], and simultaneous molecular/elemental composition [23].…”

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

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Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

103

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Abstract. Forensic evidentiary backlogs are indicative of the growing need for costeffective, high-throughput instrumental methods. One such emerging technology that shows high promise in meeting this demand while also allowing on-site forensic investigation is portable mass spectrometric (MS) instrumentation, particularly that which enables the coupling to ambient ionization techniques. While the benefits of rapid, on-site screening of contraband can be anticipated, the inherent legal implications of field-collected data necessitates that the analytical performance of technology employed be commensurate with accepted techniques. To this end, comprehensive analytical validation studies are required before broad incorporation by forensic practitioners can be considered, and are the focus of this work. Pertinent performance characteristics such as throughput, selectivity, accuracy/precision, method robustness, and ruggedness have been investigated. Reliability in the form of false positive/negative response rates is also assessed, examining the effect of variables such as user training and experience level. To provide flexibility toward broad chemical evidence analysis, a suite of rapidly-interchangeable ion sources has been developed and characterized through the analysis of common illicit chemicals and emerging threats like substituted phenethylamines.

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Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

103

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“…Typically Forensic analysis is divided into three distinct areas: forensic DNA analysis, trace evidence, and drugs and poisons [12]. Since DNA analysis was first used in forensic investigation in 1985 and is considered the indispensible tool in forensic science to identify the individual involved in a crime investigation [2].…”

Section: Microbial Forensicsmentioning

confidence: 99%

“…The challenges of badly degraded and damaged DNA samples are addressed by using reduced-sized STR or minSTR. Information on uniparental lineage markers from the Y-chromosome and mitochondrial DNA continues to accumulate in the literature to solve issues associated with evolutionary and genetic genealogy [12].…”

Section: Microbial Forensicsmentioning

confidence: 99%

Analysis of Botulinum Neurotoxin Detection by Mass Spectrometry in Forensic Samples

Hou¹

2013

J Forensic Res

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“…All CE modes employ the same instrumentation; samples can be easily analyzed subsequently as diff erencing separation mechanisms. Generally, CE is a very promising tool for clinical analysis at the present time [14][15][16][17][18][19] and it could be a simple and less time-consuming alternative technique to HPLC and GC which are also based on diff erent separation mechanisms than CE. The selectivity of CE can be utilized for separation of complicated mixtures of target analytes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Capillary Electrophoresis as a Verification Tool for Immunochemical Drug Screening

Znaleziona¹,

Petr²,

Maier³

et al. 2007

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background:The aim of this work was to develop a simple capillary electrophoretic method as the verifi cation and confi rmation tool in the screening analysis for amphetamines, opiates, benzodiazepines and cocaine and their metabolites for toxicological applications.Methods: 50 mM phosphate Tris pH 2.0 with 30 % (v/v) of methanol was used as a background electrolyte that enabled fast separation of drugs and their metabolites in saliva and urine. Verifi cation of the data from the electrophoretic method was done by High Performance Thin Layer Chromatography (HPTLC) and the immunochemical screening test QuikScreen.Results: The experimental conditions of the Capillary Electrophoresis (CE) were partially optimized (mainly the infl uence of concentration and types of additives, e.g. cyclodextrines, organic solvents) and validated; the method was used for analysing samples from drug abusers.Conclusions: The non-instrumental, immunoassay tests could only confi rm qualitative addictions and are mainly employed when the emergency detection of drugs is needed. For quantitative analysis and verifi cation of obtained results the confi rmation step is strongly recommended. The simple screening capillary zone electrophoresis method allows recognition of the most abused drugs. The agreement of the results from CE, HPTLC and QuikScreen test was more than 95 %.

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Forensic science

Cited by 11 publications

References 367 publications

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Analysis of Botulinum Neurotoxin Detection by Mass Spectrometry in Forensic Samples

Capillary Electrophoresis as a Verification Tool for Immunochemical Drug Screening

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