Foresight on Phytoconstituents and Associated Pharmacological Activities of Traditional Medicinal Plant: Saussurea costus (Falc.) Lipschitz

Vijayalakshmi, M.; Umamaheswari, A; Agalya, B.; Jegasubramaniam, S. N.; Prabu, S.

doi:10.1007/s40495-022-00287-8

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…The current literature survey studies focused on understanding the medicinal and religious importance of S. obvallata. From the earlier investigations carried out 10 ,it is clear that the species possess various medicinal properties and upon which advanced research can be done, however our studies conclude that S. obvallata plant is very useful medicinal plant which could be cultivated on small areas as a micro initiative towards germplasm conservation and religious practices of worshipping the plant and its products in India shall be very beneficial method to preserve and conserve them for future so that research findings can be carried out to screen the important metabolites that can be used for therapeutics and thus the plant can be regarded as spirituo-scientific plant of India.…”

Section: Discussionmentioning

confidence: 99%

An overview on Saussurea obvallata: A spirituo-scientific plant of India

Jyothi,

Srinivas Murthy

2023

J. Drug Delivery Ther.

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Saussurea obvallata (S. Obvallata) is one of the beneficial plant which has been used in various countries as traditional medicines. Some of the species have been identified as endangered ones. Realizing the importance of one of S. Obvallata in ornamental, spiritual and traditional purposes, a review studies was undertaken to understand the scientific investigations carried out on the plant and spiritual practices in India have been focused as a part of germplasm conservation in India. Keywords: S. obvallata, Brahma kamal, medicinal, spiritual plant

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Section: Discussionmentioning

confidence: 99%

An overview on Saussurea obvallata: A spirituo-scientific plant of India

Jyothi,

Srinivas Murthy

2023

J. Drug Delivery Ther.

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“…Saussurea lappa root contains about 13.25% and 79.80% of monoterpenoids and sesquiterpenoids respectively. The main types of sesquiterpenes are dehydrocostus lactone (C15H18O2) or 3,6,9-trimethylidenedodecahydroazuleno [4,5-b]furan-2-one, and costunolide (C15H20O2) or eudesma-5,11(13)dien-8,12-olide [10].…”

Section: Possible Antifungal Components In Saussurea Lappa Rootmentioning

confidence: 99%

“…It belongs to Asteraceae family, and known as other names such as Aplotaxis lappa Decne., Aucklandia costus Falc., Aucklandia lappa Decne., Saussurea lappa (Decne.) Sch.Bip., Theodorea costus Kuntze, as well as popularly known as Qusthul Hindi [10].…”

Section: Introductionmentioning

confidence: 99%

Exploring Antifungal Potential of Qusthul Hindi (Saussurea lappa) Root against Candida albicans: A Systematic Review

Nastiti,

Syakdiyah,

Imansari

2023

J. Sains Kes.

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Candida albicans is a microflora fungal species that can be invasive in immunocompromised conditions. Challenges in its therapy include antifungal drug resistance, which encourages research to find natural ingredients to help treat fungal infections caused by Candida albicans. One of the natural ingredients empirically known to be useful as an antimicrobial is Saussurea lappa, as known as Qusthul Hindi. This study aims to review previous studies to find out the antifungal activity of this plant root extract against Candida albicans. The method used is a systematic review, by identifying, sorting, and reviewing scientific publications, particularly research articles in the specified database and time period. A few qualified scientific publications were then reviewed, and it was found that all these studies proved the antifungal activity of Saussurea lappa root extract in vitro. Saussurea lappa root provides potential to inhibit Candida albicans in vitro. However, scientific publications have not been found regarding the Saussurea lappa root extract in modulating immunity under conditions of fungal infection, nor has it been tested against Candida albicans in vivo. Therefore, further research is required to be able to utilize Saussurea lappa root in the treatment of human fungal infection.

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“…It is an important perennial medicinal plant, well known and widely used in Unani Ayurveda, Tibetan and Chinese folkloric remedies for many cases since ancient times [13][14][15][16][17]. Using an in-silico test, Hajji et al [18] had examined the chemical components of this plant as antiviral agents. The docking and molecular dynamics examinations' process were accomplished between SARS-CoV-2 main protease (Mpro) and biochemical constituents derived from S. lappa like costunolide.…”

Section: Introductionmentioning

confidence: 99%

In-Silico Anti-SARS-CoV-2 Activity of Different Bioactives Green-Extracted from the Medicinal Plant Saussurea lappa Clarck

Abdulqahar,

Hussein

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Since the COVID-19’s outbreak in 2019, efforts are continued to scan health and immune enhancing action of the historically known medicinal herbs. This paper describes a thorough in-silico method certain phytochemicals from Saussurea lappa Clarke, with a focus on the main protease (Mpro), papain like protease (PLpro) and the spike glycoprotein of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of our study is to explore the green-extracted phyto-bioactive compounds’ activities as potential SARS-CoV-2 inhibitor. Unlike previous studies, this study tried to investigate most polar, semipolar and nonpolar compounds from S. lappa. The plant’s dried roots oil was extracted via supercritical CO2 extractor to collect the polar and semipolar compounds. The rest semipolar and polar compounds were hydroalcoholic extracted with (50%Ethanol) from the defatted residues by the aid of sonication, filtered and freeze-dried. The two fractions were chemically profiled by subjecting to HPLC and GC-MS analyses, and results revealed thirty-three different polyphenolic compounds and terpenoids. The distinguished bioactives were subjected to the in-silico study. Among these compounds, the most effective predicted inhibitors by molecular docking were ellagic acid and rutin as inhibitors for Mpro, spike protein and PLpro with vina scores equal -8.4, -8.9 and -11.6 respectively. As far as we know, this is the first study which reports the inhibitory activity against SARS-CoV-2 of both of the green extracted hydroalcoholic extract and oil of S. lappa in an attempt to examine as much as possible of the polar semipolar and nonpolar bioactives, which were very promising. However, this work interpret only one type of computational analysis of selected phyto-bioactive compounds and further surveys are required to confirm their suitability as anti-COVID-19 treatment.

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Foresight on Phytoconstituents and Associated Pharmacological Activities of Traditional Medicinal Plant: Saussurea costus (Falc.) Lipschitz

Cited by 7 publications

References 37 publications

An overview on Saussurea obvallata: A spirituo-scientific plant of India

An overview on Saussurea obvallata: A spirituo-scientific plant of India

Exploring Antifungal Potential of Qusthul Hindi (Saussurea lappa) Root against Candida albicans: A Systematic Review

In-Silico Anti-SARS-CoV-2 Activity of Different Bioactives Green-Extracted from the Medicinal Plant Saussurea lappa Clarck

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