Foreword

DeMaeyer, Edouard M.; Forbes, Allan L.; Kahn, Samuel G.

doi:10.1016/b978-0-12-177060-0.50005-0

Cited by 4 publications

(4 citation statements)

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“…Iron deficiency is common worldwide and in infants can cause severe neurological deficit (1). In contrast, iron in excess of cellular needs is toxic and dietary overload or hereditary hemochromatosis (HH) 1 leads to tissue iron deposition and injury (2,3). Alterations of iron pools have been implicated in diverse human diseases, including neurodegenerative disease, aging, atherosclerosis, cancer, and microbial infection (4).…”

mentioning

confidence: 99%

Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

Attieh

Mukhopadhyay

Seshadri

et al. 1999

Journal of Biological Chemistry

128

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The balance required to maintain appropriate cellular and tissue iron levels has led to the evolution of multiple mechanisms to precisely regulate iron uptake from transferrin and low molecular weight iron chelates. A role for ceruloplasmin (Cp) in vertebrate iron metabolism is suggested by its potent ferroxidase activity catalyzing conversion of Fe 2؉ to Fe 3؉ , by identification of yeast copper oxidases homologous to Cp that facilitate high affinity iron uptake, and by studies of "aceruloplasminemic" patients who have extensive iron deposits in multiple tissues. We have recently shown that Cp increases iron uptake by cultured HepG2 cells. In this report, we investigated the mechanism by which Cp stimulates cellular iron uptake. Cp stimulated the rate of non-transferrin 55 Fe uptake by iron-deficient K562 cells by 2-3-fold, using a transferrin receptor-independent pathway. Induction of Cp-stimulated iron uptake by iron deficiency was blocked by actinomycin D and cycloheximide, consistent with a transcriptionally induced or regulated transporter. Cp-stimulated iron uptake was completely blocked by unlabeled Fe 3؉ and by other trivalent cations including Al 3؉ , Ga 3؉ , and Cr 3؉ , but not by divalent cations. These results indicate that Cp utilizes a trivalent cation-specific transporter. Cp ferroxidase activity was required for iron uptake as shown by the ineffectiveness of two ferroxidase-deficient Cp preparations, copper-deficient Cp and thiomolybdate-treated Cp. We propose a model in which iron reduction and subsequent re-oxidation by Cp are essential for an iron uptake pathway with high ion specificity.

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mentioning

confidence: 99%

Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

Attieh

Mukhopadhyay

Seshadri

et al. 1999

Journal of Biological Chemistry

128

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“…[ 21 ]. Expansion of plasma volume is greater than that of red cell mass and leads to a decline in haemoglobin and haematocrit [ 18 ], with little change in average red-cell haemoglobin concentration, or MCHC [ 16 ]. MCHC is, therefore, a useful indicator of iron deficiency although by definition it can only diagnose iron deficiency at the stage of anaemia.…”

Section: Discussionmentioning

confidence: 99%

“…Anaemia was defined as Hb <11 g/dl, severe anaemia as Hb <8 g/dl, and iron-deficient erythropoiesis as ZPP concentration > 2.7 μg ZP/g Hb [ 14 , 16 ]. Low MCHC was defined as <32 g/d [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Zinc erythrocyte protoporphyrin as marker of malaria risk in pregnancy - a retrospective cross-sectional and longitudinal study

Senga

Koshy

Brabin

2012

Malar J

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BackgroundThe effects of iron interventions and host iron status on infection risk have been a recurrent clinical concern, although there has been little research on this interaction in pregnant women.MethodsCross-sectional and longitudinal analyses were undertaken to determine the association of whole blood zinc erythrocyte protoporphyrin (ZPP) with malaria parasitaemia in pregnant women attending antenatal and delivery care at Montfort and Chikwawa Hospitals, Shire Valley, Malawi. Prevalence of antenatal, delivery and placental malaria was assessed in relation to maternal ZPP levels. The main outcome measures were prevalence of peripheral and placental Plasmodium falciparum parasitaemia and odds ratios of malaria risk.ResultsA total of 4,103 women were evaluated at first antenatal visit, of whom at delivery 1327 were screened for peripheral and 1285 for placental parasitaemia. Risk of malaria at delivery (peripheral or placental) was higher in primigravidae (p < 0.001), and lower (peripheral) with use of intermittent preventive anti-malarials during pregnancy (p < 0.001). HIV infection was associated with increased malaria parasitaemia (p < 0.02, peripheral or placental). Parasitaemia prevalence was lower in women with normal ZPP levels compared to those with raised concentrations at both first antenatal visit (all gravidae, p = 0.048, and at delivery (all gravidae, p < 0.001; primigravidae, p = 0.056). Between first antenatal visit and delivery women who transitioned from raised (at first antenatal visit) to normal ZPP values (at delivery) had lower peripheral parasitaemia prevalence at delivery compared to those who maintained normal ZPP values at both these visits (all gravidae: 0.70, 95%CI 0.4-1.1; primigravidae: 0.3, 0.1-0.8). In regression analysis this difference was lost with inclusion of HIV infection in the model.ConclusionsRaised ZPP concentrations in pregnancy were positively associated with P. falciparum parasitaemia and were probably secondary to malaria inflammation, rather than indicating an increased malaria risk with iron deficiency. It was not possible from ZPP measurements alone to determine whether iron deficiency or repletion alters malaria susceptibility in pregnancy.

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“…The current prevalence of anemia is estimated at 30% of the world population (3). This figure translates to nearly 1.5 billion people, and significant differences in incidence occur between the developed regions (North America, Japan, and Europe), where 8% of the population are anemic, and the developing countries, where 36% are anemic.…”

Section: Prevalence Of Anemia and Iron Deficiencymentioning

confidence: 98%

Current concepts in iron deficiency anemia

Skikne

1988

Food Reviews International

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Iron deficiency is one of the commonest worldwide nutritional disorders and anemia is a frequent manifestation of its presence. Children and menstruating women are most commonly affected due to their increased iron requirements. The incidence of iron deficiency is greatest in developing countries due to the ingestion of a diet from which iron is poorly bioavailable. Besides anemia, other nonhematological complications of iron deficiency may occur which have uncertain long-term consequences. While iron supplementation is beneficial in targeted segments of a population, iron fortification of the diet is a preferable method to prevent iron deficiency. A battery of laboratory measurements are necessary for assessing iron status in population studies, and careful long-term screening is recommended to examine the effects of iron fortification programs.

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Foreword

Cited by 4 publications

References 0 publications

Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

Zinc erythrocyte protoporphyrin as marker of malaria risk in pregnancy - a retrospective cross-sectional and longitudinal study

Current concepts in iron deficiency anemia

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