“…However, most of these approaches do not properly address environmental realism in terms of, for example, the spatial and temporal variability of exposure and ecological scenarios (affecting both exposure and effects) (De Laender et al, 2014, 2015, the interactions among individuals and populations and the co-occurrence with other stress factors (such as chemical or physical ones). A recent joint scientific opinion document from the three scientific committees of the European Commission (EC, 2013;Vighi, 2013) tried to address the new challenges for risk assessment for human health and the environment. Among the points devised, a number were related to the improvement of environmental exposure assessment (EEA) in ERA.…”