Forkhead box M1 expression in pulmonary squamous cell carcinoma: correlation with clinicopathologic features and its prognostic significance

Yang, Doo Kyung; Son, Chang-Woo; Lee, Soo Keol; Choi, Phil Jo; Lee, Jun Young; Roh, Mee Sook

doi:10.1016/j.humpath.2008.10.001

Cited by 61 publications

(61 citation statements)

References 22 publications

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“…As a typical cell-cycle-related transcription factor, one of the key roles of FoxM1 in carcinogenesis is to promote tumor proliferation (9). In addition, upregulation of FoxM1 is a frequent event in different tumor types, and FoxM1 deficiency triggers reduced cellular proliferation or even growth arrest (10)(11)(12)(13)(14), which suggests that FoxM1 may play an important role in tumorigenesis and progression. Our results revealed that overexpression of FoxM1 occurred from gastritis to gastric cancer progression and H. pylori-induced FoxM1 expression in vivo and in vitro, so FoxM1 might take part in the early stage of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Aberrant expression of FoxM1 is involved in several tumor types, including hepatocellular carcinoma, basal cell carcinoma, breast cancer, lung cancer, prostate cancer, glioblastomas, and gastric cancer (10)(11)(12)(13)(14)(15)(16)(17)(18), which implies an oncogene role in carcinogenesis. We previously reported that FoxM1 is upregulated in gastric cancer, and its inhibition leads to cellular senescence (18), but the relevance of H. pylori infection and FoxM1 expression associated with the pathogenesis of gastric cancer remains undefined.…”

Section: Introductionmentioning

confidence: 99%

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FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

Feng

Wang

Zeng

et al. 2013

Molecular Cancer Research

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Helicobacter pylori (H. pylori) infections are strongly implicated in human gastric mucosa-associated diseases. Forkhead box M1 (FoxM1), a key positive regulator of cell proliferation, is overexpressed in gastric cancer. MicroRNAs are important post-transcriptional regulators of gene expression. In this study, the effects of H. pylori infection on FoxM1 expression and possible mechanisms of carcinogenesis were explored. The expression of FoxM1 was gradually increased in human gastric specimens from inflammation to cancer. FoxM1 upregulation was time-and concentration-dependent in gastric epithelial-derived cell lines infected with H. pylori. CagA, a key virulence factor of H. pylori, was associated with increased FoxM1 expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

Feng

Wang

Zeng

et al. 2013

Molecular Cancer Research

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“…The association of FoxM1 expression with poor prognosis has been reported by other groups in many human cancers, including LC [13][14][15]. It has been found that FoxM1 expression was related with clinical factors and functioned as a critical predictor in prognosis in 69 cases of SCC patients, but not in ADC [14].…”

Section: Discussionmentioning

confidence: 66%

“…It has been found that FoxM1 expression was related with clinical factors and functioned as a critical predictor in prognosis in 69 cases of SCC patients, but not in ADC [14]. Recently, Liu and his colleagues [15] demonstrated that FoxM1 could serve as an independent factor for prognosis in 68 NSCLC patients, including 37 ADC and 19 SCC.…”

Section: Discussionmentioning

confidence: 99%

“…In NSCLC, it has been reported that FoxM1 is associated with poor prognosis of NSCLC patients by enhancing tumor metastasis [13]. In addition, it has been shown that FoxM1 overexpression correlated with the short survival of patients using immunohistochemistry analysis of 69 cases of squamous cell carcinoma specimens [14].…”

Section: Elevated Foxm1 Expression Predicts Shorter Overall Survival mentioning

confidence: 99%

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Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters

Wang

Duan

2016

Open Life Sciences

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Objectives: As the member of the Fox family of transcription factors, Forkhead box M1 (FoxM1) is known to be critical in pathogenesis and development of many solid tumors. However, the clinical value and expression pattern in non-small cell lung cancer (NSCLC) is still poorly understood. Methods: In this study, real-time PCR was mainly applied to examine the gene expression levels of FoxM1 in 120 pairs of clinical NSCLC tissues, which were classified into different groups according to smoking status, lymph node metastasis, and tumor grade. By utilizing the online Kaplan-Meier plotter, overall survival analysis was performed to study the correlation between FoxM1 expression and prognosis of lung cancer (LC) patients. Afterwards, the correlation of FoxM1 gene expression and the clinical pathological parameters was examined by κ2 test in these 120 NSCLC patients. Results: FoxM1 was found to be aberrantly upregulated in NSCLC patients, and its overexpression was correlated to groups designated as smokers, cases of positive lymph node metastasis and cases of advanced tumor grades. Online survival analysis showed that high expression of FoxM1 predicted shorter overall survival of NSCLC patients. Additionally, FoxM1 upregulation was statistically correlated with positive smoking history, lymph node metastasis and higher tumor grades. Conclusion: FoxM1 is overexpressed in cancerous tissues and is associated with the poor prognosis of NSCLC patients. Our results provide insights into the utility of FoxM1 as an important biomarker and prognostic factor for NSCLC.

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Deregulation of FoxM1b leads to tumour metastasis

et al. 2010

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The forkhead box M1b (FoxM1b) transcription factor is over-expressed in human cancers, and its expression often correlates with poor prognosis. Previously, using conditional knockout strains, we showed that FoxM1b is essential for hepatocellular carcinoma (HCC) development. However, over-expression of FoxM1b had only marginal effects on HCC progression. Here we investigated the effect of FoxM1b expression in the absence of its inhibitor Arf. We show that transgenic expression of FoxM1b in an Arf-null background drives hepatic fibrosis and metastasis of HCC. We identify novel mechanisms of FoxM1b that are involved in epithelial–mesenchymal transition, cell motility, invasion and a pre-metastatic niche formation. FoxM1b activates the Akt-Snail1 pathway and stimulates expression of Stathmin, lysyl oxidase, lysyl oxidase like-2 and several other genes involved in metastasis. Furthermore, we show that an Arf-derived peptide, which inhibits FoxM1b, impedes metastasis of the FoxM1b-expressing HCC cells. The observations indicate that FoxM1b is a potent activator of tumour metastasis and that the Arf-mediated inhibition of FoxM1b is a critical mechanism for suppression of tumour metastasis.

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Forkhead box M1 expression in pulmonary squamous cell carcinoma: correlation with clinicopathologic features and its prognostic significance

Cited by 61 publications

References 22 publications

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

Forkhead box 1 expression is upregulatedin non-small cell lung cancer and correlateswith pathological parameters

Deregulation of FoxM1b leads to tumour metastasis

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