2021
DOI: 10.1016/j.exer.2021.108725
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Forkhead domain inhibitory-6 attenuates subconjunctival fibrosis in rabbit model with trabeculectomy

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Cited by 8 publications
(8 citation statements)
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“… 40 , 41 FOXM1 is a key transcription factor regulating cell proliferation and survival, and its inhibition has been documented to attenuate tissue or organ fibrosis in many studies. 20 , 38 Consistently, topical application of FDI-6 markedly reduced alkali-induced expression of profibrotic factors, including FN and α-SMA at the mRNA and protein levels, which was further confirmed by Masson staining and immunohistochemical staining of α-SMA.…”
Section: Discussionmentioning
confidence: 56%
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“… 40 , 41 FOXM1 is a key transcription factor regulating cell proliferation and survival, and its inhibition has been documented to attenuate tissue or organ fibrosis in many studies. 20 , 38 Consistently, topical application of FDI-6 markedly reduced alkali-induced expression of profibrotic factors, including FN and α-SMA at the mRNA and protein levels, which was further confirmed by Masson staining and immunohistochemical staining of α-SMA.…”
Section: Discussionmentioning
confidence: 56%
“… 21 , 22 Our previous study found that FDI-6 can bind directly to FOXM1, prevent FOXM1 from binding to its genomic target, suppress TGF-β1-induced ECM proteins synthesis, myofibroblast activation, cellular proliferation, and migration in cultured rabbit tenon's fibroblasts in vitro and attenuate subconjunctival fibrosis secondary to trabeculectomy in vivo. 20 Moreover, infiltration of a number of inflammatory cells into the conjunctival epithelium caused by trabeculectomy was also alleviated by FDI-6 treatment. 20 To the best of our knowledge, no study has previously investigated the role of FDI-6 in ocular neovascularization.…”
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confidence: 96%
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