Wrinkling, which is primarily caused by insufficient blank holder force, is a significant issue that induces inconsistencies in forming parts, particularly in the deep drawing process. In this article, an investigation of the wrinkling in the deep drawing process of two-layer sheets is performed through an analytical approach, numerical method, and experimental tests. Increasing in the blank holder force, the process is under control by the proposed algorithm. Consequently, it aims to find the minimum required blank holder force to avoid wrinkling. The energy technique is utilized to predict the wrinkling in the analytical approach. Similarly, finite element simulations are implemented to investigate the effect of forming parameters on wrinkling. The experimental tests are performed to verify the analytical and numerical results. The impact of the material properties and stacking sequences (lay-up) on blank holder force and forming force are studied. Results show that the optimum blank holder force is dependent on the material properties, blank geometry, and layer stacking sequences. Also, a good agreement between analytical, numerical, and experimental results is achieved.