Formal Total Syntheses of (+)‐ and (–)‐ar‐Macrocarpene via Rh^(I)‐BINAP Catalyzed Conjugate Addition

Abstract

Catalytic asymmetric formal total syntheses of both antipodes of sesquiterpene, (+)-ar-macrocarpene (1) and (-)-ar-macrocarpene (ent-1) has been achieved from 5,5-dimethyl-(3-p-tolyl)cyclohexanone 12. Enantioenriched compound 12 was obtained in excellent yield with 96 % ee by cata- [a]