Formaldehyde-Induced Damage in Lungs and Effects of Caffeic Acid Phenethyl Ester: A Light Microscopic Study

Turkoglu, Asli Ozdem; Sarsılmaz, Mustafa; Çolakoğlu, Neriman; Zararsız, İsmail; Kuloğlu, Tuncay; Pekmez, Hıdır; Taş, Ufuk

doi:10.29333/ejgm/82597

Cited by 4 publications

(2 citation statements)

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“…This was also supported by Turkoglu et al (2008) who suggested that respiratory and transitional epithelium of nasal mucosa was more susceptible to formaldehyde damage than other epithelium. The cellular disorganization and hyperchromatic nuclei of respiratory mucosa in rabbits was identical to the findings of Javedan and Entezarizaher (1999) in rat nasal mucosa exposed to 2 and 5 ppm of formaldehyde.…”

Section: Discussionsupporting

confidence: 54%

Toxic effect of formaldehyde on the respiratory organs of rabbits: A light and electron microscopic study

2011

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In this study, the effect of direct exposure of formaldehyde in different concentration was observed in 14 rabbits aged 3-6 months and weighing 1100-1200 g. The animals were divided into two groups with six animals in each group, and two animals were kept as control. The animals of group I were exposed to 10% formalin for 12 weeks and those of group II to 40% formalin solution for 6 weeks. After completion of the experimental periods, the animals were killed and the tissue samples were collected from the nasal cavity, trachea and lungs in 10% neutral buffered formalin and Karnovsky's fixative to examine the histological and electron microscopic changes in the organs. The mucosal cells of nasal cavity showed loss of cilia and epithelial metaplasia was observed in places. There was vascular congestion and mild subepithelial odema. The tracheal epithelium was organized with hyperchromatic nuclei. There was subepithelial odema along with lymphomononuclear cellular infiltration. There was marked emphysema evident as bulla formation of air spaces due to rupture of interalveolar septum. An increased cellularity of alveolar wall was observed, resulting in its thickening. The epithelial lining of bronchioles showed loss of mucosal folds and hyperplasia of cells along with peribronchial lymphomononuclear cellular infiltration. Thickening of wall of blood vessels was evident. Congestion and haemorrhages were observed in places. It is concluded that the histopathological changes were more remarkable in the animals exposed to 40% formaldehyde for short duration than the animals exposed to 10% formaldehyde for longer duration with a more severe effect on the upper part of the respiratory tract than the lower one.

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Section: Discussionsupporting

confidence: 54%

Toxic effect of formaldehyde on the respiratory organs of rabbits: A light and electron microscopic study

2011

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“…In addition, impaired antioxidant activities of enzymes, in metabolic detoxification of oxidative by-products have been also reported in experimental animals treated with FA (22, 46). Finally, FA exposure can lead to inflammation and to a consequent excess of oxidative stress (47). Activated macrophages and neutrophils can release ROS, such as hydrogen peroxide and hypochlorite acid, that can induce LPO and MDA formation.…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde−Deoxyguanosine Adduct Formation in Workers of Pathology Wards: The Role of Air Formaldehyde Exposure

Bono

Romanazzi

Munnia

et al. 2010

Chem. Res. Toxicol.

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Background Formaldehyde is a ubiquitous pollutant to which humans are exposed. Pathologists can experience high formaldehyde exposure levels. Formaldehyde – among other properties – induce oxidative stress and free radicals, which react with DNA and lipids, leading to oxidative damage and lipid peroxidation, respectively. We measured the levels of air-formaldehyde exposure in a group of Italian pathologists and controls. We analyzed the effect of formaldehyde exposure on leukocyte malondialdehyde-deoxyguanosine adducts (M1-dG), a biomarker of oxidative stress and lipid peroxidation. We studied the relationship between air-formaldehyde and M1-dG adducts. Methods Air-formaldehyde levels were measured by personal air samplers. M1-dG adducts were analyzed by 32P-postlabelling assay. Results Reduction rooms pathologists were significantly exposed to air-formaldehyde in respect to controls and to the pathologists working in other laboratory areas (p<0.001). A significant difference for M1-dG adducts between exposed pathologists and controls was found (p=0.045). The effect becomes stronger when the evaluation of air-formaldehyde exposure was based on personal samplers (p=0.018). Increased M1dG adduct levels were only found in individuals exposed to air-formaldehyde concentrations higher than 66 μg/m3. When the exposed workers and controls were subgrouped according to smoking, M1-dG tended to increase in all the subjects but a significant association between M1-dG and air-formaldehyde was only found in not smokers (p= 0.009). Air formaldehyde played a role positive but not significant (r = 0.355, p = 0.075, Pearson correlation) in the formation of M1-dG, only in not smokers. Conclusions Working in the reduction rooms and to be exposed to air-formaldehyde concentrations higher than 66 μg/m3 is associated with increased levels of M1-dG adducts.

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Effect of formaldehyde exposure on pulmonary function tests of veterinary students in anatomy laboratory

Pour

Maleki

2011

Journal of Applied Animal Research

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Formaldehyde-Induced Damage in Lungs and Effects of Caffeic Acid Phenethyl Ester: A Light Microscopic Study

Cited by 4 publications

References 22 publications

Toxic effect of formaldehyde on the respiratory organs of rabbits: A light and electron microscopic study

Toxic effect of formaldehyde on the respiratory organs of rabbits: A light and electron microscopic study

Malondialdehyde−Deoxyguanosine Adduct Formation in Workers of Pathology Wards: The Role of Air Formaldehyde Exposure

Effect of formaldehyde exposure on pulmonary function tests of veterinary students in anatomy laboratory

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