Formaldehyde produced from d-ribose under neutral and alkaline conditions

Wang, Yujing; Shi, Chenggang; Chen, Yao; Yu, Lexiang; Li, Yiman; Wei, Yan; Li, Weiwei; He, Rong

doi:10.1016/j.toxrep.2019.02.005

Cited by 9 publications

(4 citation statements)

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“…It is therefore proposed that selective inhibition of ribose glycosylation may be used as a therapeutic strategy for the prevention of Alzheimer's disease and type 2 diabetic encephalopathy ( 71 ). Wang et al ( 72 ) also indicated that in alkaline environments, D-ribose may decompose to formaldehyde by the reverse aldol reaction, and that by determining the content of formaldehyde in various parts of mice, it was suggested that formaldehyde produced by D-ribose accumulates in the brain of the mice and that the accumulation of endogenous formaldehyde to pathological concentrations may lead to disturbance of consciousness and cognition. However, it was also hypothesized that accumulation of D-ribose-induced AGEs is an important means underlying the occurrence and development of diabetic encephalopathy ( 62 ).…”

Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Wang

Xiao

et al. 2021

Exp Ther Med

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The quality of life of patients with certain diseases may be improved through the development of technologies and advancements in pharmacology, with the aim of prolonging their life. However, congestive heart failure (CHF), as well their complications, continue to be the leading cause of disease-associated death. The mechanisms underlying the development and progression of diabetes and CHF have been uncovered in a stepwise manner and the understanding of these mechanisms has improved the management of these diseases, resulting in reduced mortality and morbidity rates; however, CHF remains the leading cause of death worldwide, particularly in developed countries. In the past decades, research has indicated that several supplements and naturally occurring compounds may be used to treat muscle weakness, for cardiac failure management, rehabilitation following myocardial ischemia-reperfusion and various complications of diabetes. D-ribose is an essential component of the respiratory, skeletal and nervous systems and is a popular compound, as its supplementation may have beneficial effects. In the present review, the physiological roles, toxic reactions and the potential use of D-ribose in the management of clinical diseases are summarized. Contents 1. Introduction 2. Physiological roles of D-ribose 3. Clinical applications of D-ribose 4. Potential hazards of high concentrations of D-ribose 5. Conclusions and future perspectives

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Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Wang

Xiao

et al. 2021

Exp Ther Med

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“…Peraxisomal catalase is capable of oxidizing formaldehyde to fumarate in the presence of hydrogen peroxide. Creation of hydrogen peroxide is the rate limiting step in this reaction, which does not account for a great deal of formaldehyde metabolism [39]. Formaldehyde is considered a hallmark of lung injury.…”

Section: Introductionmentioning

confidence: 99%

Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in lung of male Wistar rats

et al. 2019

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“…Furthermore, formaldehyde was regarded as a risk factor for age-related cognitive impairment [46]. Intraperitoneal injection with D-ribose (3.2g/kg bw, once daily) leads to an increase in formaldehyde in the mouse brain [47]. These finding suggest that high dose D-ribose intake induces toxicity.…”

Section: Discussionmentioning

confidence: 99%

D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy

Chen

et al. 2019

Aging

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Although many mechanisms have been proposed for diabetic encephalopathy in type 2 diabetes mellitus (T2DM), the risk factors for cognitive impairment in type 1 diabetes mellitus (T1DM) are less clear. Here, we show that streptozotocin (STZ)-induced T1DM rats showed cognitive impairment in both Y maze and Morris water maze assays, accompanied with D-ribose was significantly increased in blood and urine, in addition to D-glucose. Furthermore, advanced glycation end products (AGE), Tau hyperphosphorylation and neuronal death in the hippocampal CA4/DG region were detected in T1DM rats. The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM. Support for these change was demonstrated by the activation of TKT with benfotiamine (BTMP) treatment. Decreased D-ribose levels but not D-glucose levels; markedly reduced AGE accumulation, Tau hyperphosphorylation, and neuronal death; and improved cognitive ability in T1DM rats were shown after BTMP administration. In clinical investigation, T1DM patients had high D-ribose levels in both urine and serum. Our work suggests that D-ribose is involved in the cognitive impairment in T1DM and may provide a potentially novel target for treating diabetic encephalopathy.

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Formaldehyde produced from d-ribose under neutral and alkaline conditions

Cited by 9 publications

References 50 publications

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in lung of male Wistar rats

D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy

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