Formalin toxicity in hydatid liver disease

Aggarwal, Aditya; Garg, Richa

doi:10.1111/j.1365-2044.1983.tb12159.x

Cited by 28 publications

(10 citation statements)

References 10 publications

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“…Injection of a protoscolecide into CE cysts to reduce the risk of spillage of viable protoscoleces and possible recurrence is an integral part of the surgical technique employed by many surgeons around the world (143). A very broad spectrum of protoscolecidal agents, from warm water (144) to the highly toxic formalin (145), have been tested over the past 50 years, but the feasibility, safety, and efficacy of many of these compounds have generally not been determined. Details of the concentrations and modes of administration of currently available and tested protoscolecides are provided in Table 3.…”

Section: Treatment Of Cementioning

confidence: 99%

Echinococcosis: Advances in the 21st Century

Wen¹,

Vuitton²,

et al. 2019

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SUMMARY Echinococcosis is a zoonosis caused by cestodes of the genus Echinococcus (family Taeniidae). This serious and near-cosmopolitan disease continues to be a significant public health issue, with western China being the area of highest endemicity for both the cystic (CE) and alveolar (AE) forms of echinococcosis. Considerable advances have been made in the 21st century on the genetics, genomics, and molecular epidemiology of the causative parasites, on diagnostic tools, and on treatment techniques and control strategies, including the development and deployment of vaccines. In terms of surgery, new procedures have superseded traditional techniques, and total cystectomy in CE, ex vivo resection with autotransplantation in AE, and percutaneous and perendoscopic procedures in both diseases have improved treatment efficacy and the quality of life of patients. In this review, we summarize recent progress on the biology, epidemiology, diagnosis, management, control, and prevention of CE and AE. Currently there is no alternative drug to albendazole to treat echinococcosis, and new compounds are required urgently. Recently acquired genomic and proteomic information can provide a platform for improving diagnosis and for finding new drug and vaccine targets, with direct impact in the future on the control of echinococcosis, which continues to be a global challenge.

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Section: Treatment Of Cementioning

confidence: 99%

Echinococcosis: Advances in the 21st Century

Wen¹,

Vuitton²,

et al. 2019

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“…Formalin has been rarely used for the risk of death from acidosis and obliterative cholangitis. [ 3 ] Silver nitrate could lead to biliary epithelium injury. [ 4 ] The HS, from 3% to 30%, is recommended by WHO/OIE and has been used for a long time.…”

Section: Introductionmentioning

confidence: 99%

The association of hypernatremia and hypertonic saline irrigation in hepatic hydatid cysts

Zeng

et al. 2017

Medicine

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Rationale:Hypernatremia is a rare but fatal complication of hypertonic saline (HS) irrigation in hepatic hydatid disease. It needs careful monitoring and treatment.Patient concerns:A 28-year-old woman with hepatic hydatid cysts who received operation treatment developed electrolyte disturbances. We also conducted a retrospective study about influence of HS application on electrolytes in patients with hepatic hydatid disease receiving surgery.Diagnoses:Hypernatremia, developed after HS irrigation.Interventions:Normal saline, 5% dextrose and other supportive treatment were administered. In the retrospective study, a comparison of electrolyte and glucose fluctuation was made among different HS application groups.Outcomes:The patient developed hypernatremia after irrigation with HS and died from severe complications. Although some cases of complications are found, no significant relationship between HS irrigation and hypernatremia was reported according to the retrospective study.Lessons:Hypernatremia after HS irrigation remains rare but might cause severe complications. Monitoring and appropriate treatment are needed to improve prognosis.

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“…La meilleure option thérapeutique est l’exérèse chirurgicale du kyste intact pour éviter la récidive locale et le risque de choc anaphylactique [ 6 ]. Si l’exérèse est impossible, le contenu du kyste peut être aspiré en per opératoire ou sous guidage échographique puis irrigué avec une solution scolicidale: solution saline concentrée à 20%, peroxyde d´hydrogène à 3%, cétrimide à 1,5% associé à la chlorhexidine à 0,15% (10% Savlon ® ), l´alcool éthylique à 95%, la polyvinylpyrrolidone iodée à 10% (Bétadine ® ) [ 9 , 10 ]. Le traitement médical repose sur l´utilisation de l´albendazole [ 1 , 3 ].…”

Section: Discussionunclassified