Formation and Characterization of <i>Z</i>-Isomer-Enriched Carotenoid-Loaded Microparticles with Poly(vinylpyrrolidone) Using a Spray Drying Technique

Honda, Masaki; Zhang, Yelin; Kageyama, Hakuto; Hibino, Takashi; Goto, Motonobu; Nishida, Yasuhiro

doi:10.1021/acs.iecr.3c03450

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…Materials employed in both areas to improve these products’ performance, stability, and bioavailability include biopolymeric matrices such as chitosan, alginates, casein, or gelatin, as well as lipidic structures like liposomes or emulsions [ 30 ]. In the specific case of carotenoids, commonly utilized micro- and nanomaterials are gum Arabic [ 31 ], maltodextrin [ 32 ], fructo-oligosaccharides and inulin [ 33 ], and poly(vinylpyrrolidone) [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Ortega-Regules,

Martínez-Thomas,

Schürenkämper-Carrillo

et al. 2024

Plants

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Carotenoids constitute compounds of significant biological interest due to their multiple biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series of metabolic abnormalities (e.g., hypertension, obesity, and atherogenic dyslipidemia) that can affect children, adolescents, and the elderly. The treatment of MetS involves numerous medications, which, despite their efficacy, pose challenges due to prolonged use, high costs, and various side effects. Carotenoids and their derivatives have been proposed as alternative treatments to MetS because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, and downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive to pH, light exposure, and temperature. This review addresses the activity of carotenoids such as lycopene, lutein, fucoxanthin, astaxanthin, crocin, and β-carotene towards MetS. It includes a discussion of sources, extraction methods, and characterization techniques for analyzing carotenoids. Encapsulation approaches are critically reviewed as alternatives to prevent degradation and improve the biological performance of carotenoids. A brief overview of the physiopathology and epidemiology of the diseases, including MetS, is also provided.

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Section: Introductionmentioning

confidence: 99%

“…Arabic [31], maltodextrin [32], fructo-oligosaccharides and inulin [33], and poly(vinylpyrrolidone) [34].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Ortega-Regules,

Martínez-Thomas,

Schürenkämper-Carrillo

et al. 2024

Plants

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Complex formation and stabilization of Z‐isomer‐enriched astaxanthin esters derived from Haematococcus lacustris with water‐soluble carriers via spray drying

Sakaguchi,

Ghosh,

Banik

et al. 2024

Euro J Lipid Sci & Tech

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To enhance the water solubility and bioavailability of astaxanthin esters, inclusion complexes of Z‐isomer‐enriched astaxanthin esters with water‐soluble carriers were prepared using a spray drying technique. A food‐grade Haematococcus alga extract was used as the source of astaxanthin esters, and the Z‐isomerization was performed via direct heating of the extract. Polyvinylpyrrolidone (PVP) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) were used as water‐soluble carriers. The effects of spray drying conditions on the encapsulation efficiency of astaxanthin esters in the carriers and the total Z‐isomer ratio of encapsulated astaxanthin esters were investigated, and the physical properties and storage stability of the resulting composites were evaluated. Under optimum spray drying conditions, efficient production of highly water‐soluble Z‐isomer‐rich astaxanthin esters was achieved in both carriers: >95% encapsulation efficiency and >55% total Z‐isomer ratio. The physical properties, such as surface morphology and particle size distributions, of the resulting particles differed significantly between PVP and HP‐β‐CD. Storage tests demonstrated that the formulated Z‐isomer‐rich astaxanthin esters were highly stable. Our findings will contribute to the practical applications of Z‐isomer‐rich astaxanthin materials.Practical Applications: The formulation technology developed in this study has the potential to address the industrial challenges of using astaxanthin, that is, low water solubility and low bioavailability. Furthermore, the low storage stability of astaxanthin Z‐isomers, which hinders their industrial use, can be solved simultaneously. The resulting Z‐isomer‐rich astaxanthin powders are expected to be used in a wide range of applications, including nutraceuticals, cosmetics, and animal feeds.

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Formation and Characterization of Z-Isomer-Enriched Carotenoid-Loaded Microparticles with Poly(vinylpyrrolidone) Using a Spray Drying Technique

Cited by 2 publications

References 57 publications

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Complex formation and stabilization of Z‐isomer‐enriched astaxanthin esters derived from Haematococcus lacustris with water‐soluble carriers via spray drying

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