Formation and Characterization of Mefenamic acid-Nicotinamide Cocrystal during Co-milling Based on X-ray Powder Diffraction Analysis

Abstract

Mefenamic acid (MFA) and Nicotinamide (NIC) cocrystal formation in co-milling treatment was investigated by x-ray powder diffractometry (XRPD). Two polymorphic form of Mefenamic acid (MFA form I and MFA form II) were used to form a cocrystal with nicotinamide. Co-milling treatment was carried out at room temperature in a 1:2 molar ratio of MFA and NIC for various times up to 60 min. Samples were analyzed by XRPD. The XRPD showed that MFA form I and MFA form II formed cocrystal with NIC in the same diffractograms pattern. There was no intermediate amorphous form during milling process. The cocrystal formation mechanism was predicted via intermediate eutectic mixtures. The cocrystal formation from MFA form II (15 min) was faster than from MFA form I (45 min) which may explained by variations unit cell dimensions of MFA form I and MFA form II and also the polymorphic transformation of MFA form I.

Design, Synthesis and Investigation of Mefenamic Acid Containing Thiazolidine-4-one

“…A precipitate was leached using a Buechner funnel, and the result was recrystallized from ethanol. Table (1) lists the physical constants of the prepared Schiff's bases. In a two-neck, round-bottom flask containing a condenser, 0.002 mol of Schiff base was dissolved in 15 ml of dioxane and stirred for ten minutes.…”

“…2-[N- (2,3-dimethylphenyl)amino]benzoic acid (mefenamic acid) or ponstan, is a kind of nonsteroidal anti-inflammatory medication (NSAID) that demonstrates properties that are anti-inflammatory, analgesic, and antipyretic. [1,2]. It has a wide range of applications as a therapeutic agent, and in 2012 alone, more than 100 million treatments with NSAIDs were carried out all over the world.…”

Peningkatan Disolusi Asam Mefenamat Melalui Kokristalisasi dengan Para-Aminobenzoic Acid Menggunakan Metode Liquid‐Assisted Grinding

“…Penambahan sejumlah kecil pelarut dapat mempercepat kokristalisasi (Brittain, 2012;Bunaciu, Udristioiu and Aboul-Enein, 2015). (Utami, Nugrahani and Ibrahim, 2016) Gambar 5. Pola XRD asam mefenamat (A) dan kokristal AM-PABA (B)…”

New Sodium Mefenamate – Nicotinamide Multicomponent Crystal Development to Modulate Solubility and Dissolution: Preparation, Structural, and Performance Study

“…This compound is soluble in water and utilized as a coformer for some cocrystals. [12][13][14]45 In addition to combination with fenamic compounds, 13 NA was also reported to make cocrystals with various nitrogen heterocycle-containing aromatic dicarboxylic acids 14 and increase the solubility of fenofibrate by approximately 2-fold after cocrystallization. 45 Here, we attempted to combine SM with NA to develop superior properties for the parent drug.…”