Formation and clinical importance of postoperative peritoneal adhesions

Başbuğ, Murat; Arıkanoğlu, Zülfü

doi:10.5799/ahinjs.01.2010.02.0028

Cited by 1 publication

(1 citation statement)

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“…In conclusion, PRP seems to be suppressing the inflammatory process 41 . TGF-B is one of the cytokines involved in adhesion pathophysiology 42 . In the study of Murat et al, adhesions were decreased after the PRP administration; additionally, the TGF-B expression in the adhesion foci where PRP was administered has been shown to decrease 25 .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

Anğın

Gün

Sakin

et al. 2019

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29Our aim was to investigate the effect of platelet-rich plasma (PRP) derivatives, which 30 can be produced from the patient's own blood and have minimal side effects, on 31 endometriosis. To the best of our knowledge, this is the first study in the literature that studies 32 the relationship between PRP and endometriosis. Endometriosis foci were created in the first 33 operation. In the second operation (30 th day) groups were formed. Group 1 (n= 8) was 34 administered saline, group 2 (n= 7) leukocyte-and platelet-rich plasma (L-PRP), and group 3 35 (n= 8) pure platelet-rich plasma (P-PRP). Group 4 (n= 10) was used to obtain PRP. In the last 36 operation (60 th day), the endometriotic foci were measured, and then excised. There was no 37 statistically significant difference between the pre and post volumes of the endometriotic foci, 38 between their volume differences and volume difference rates (p > .05). However, it was 39 observed that existing implant volumes in all groups decreased statistically significantly 40 within their own groups by the end of the experiment compared to the previous volumes (p < 41 .05). When the implants were assessed through histopathological scoring in terms of edema, 42 vascular congestion, inflammatory cell infiltration, hemorrhage, epithelial line, and 43 hemosiderin accumulation and immunohistochemical staining in terms of VEGF, there was 44 no significant difference in the comparison between the groups. Although L-PRP and P-PRP 45 generated more reduction in the endometriosis foci, they did not create any statistical 46 differences. 48Endometriosis, which is described as the presence of endometrial gland and stroma 49 outside the uterine cavity, is an important women's health problem seen in 6-10% of women 50 that causes degradation in the quality of life with clinical effects, such as infertility, 3 51 dysmenorrhea, dyspareunia and chronic pelvic pain 1-4 . Its pathophysiology has not yet been 52 fully resolved, and an effective treatment for it has not yet been found 5,6 . 53

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Section: Discussionmentioning

confidence: 99%