Formation and Isolation of Antibodies Specific for Nucleotides

Grabar, P; Avraméas, Stratis; Taudou, B; Salomon, J.

doi:10.1007/978-3-642-87668-4_7

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Based on these findings it seemed reasonable to conclude that the spleen of a normal animal contains a number of resting lymphocytes with specificity for autologous cellular antigens. Our results are therefore in agreement with those showing that mice injected with LPS or with killed gram-negative bacteria develop anti-single stranded and anti-double stranded DNA antibodies (Christian et al 1965, Grabar et al 1968, Fournie et al 1975. In these studies Fournie et al also found a direct correlation between the amount of anti-DNA antibodies and the amount of Lipid A injected.…”

Section: Demonstration Of Self-reactive B Cellssupporting

confidence: 93%

Immunological Tolerance Affects Only a Subpopulation of the Antigen‐Specific B Lymphocytes: Evidence against Clonal Deletion as the Mechanism of Tolerance Induction

Fernández

Hammarström

Möller

et al. 1979

Immunological Reviews

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Section: Demonstration Of Self-reactive B Cellssupporting

confidence: 93%

Immunological Tolerance Affects Only a Subpopulation of the Antigen‐Specific B Lymphocytes: Evidence against Clonal Deletion as the Mechanism of Tolerance Induction

Fernández

Hammarström

Möller

et al. 1979

Immunological Reviews

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“…Many clinical or experimental conditions involving bacterial (13) or viral infections (11,14,15) have been reported to favor the formation of antinuclear antibodies. Such antibodies have also been found in sera from animals immunized with killed gram-negative bacteria (16,17).…”

mentioning

confidence: 88%

Release of Dna in Circulating Blood and Induction of Anti-Dna Antibodies After Injection of Bacterial Lipopolysaccharides

Fournié

Lambert

Miescher

1974

The Journal of Experimental Medicine

169

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The present data demonstrate the induction of antisingle-stranded (SS) DNA and antidouble-stranded DNA antibodies in various strains of mice, including athymic C57BL/6 nude mice, after the injection of bacterial lipopolysaccharide (LPS). This anti-DNA response is dose dependent and varies quantitatively according to the strain of the injected mice. It is not correlated to the H-2 histocompatibility locus nor to the immune response to LPS. The lipid A fraction appears to be the active part of the LPS molecule for this particular effect. In addition, it was found that DNA is released in circulating blood a few hours after the injection of LPS. Most of the DNA released has physicochemical and immunochemical characteristics of SS DNA. Therefore, the anti-DNA response induced by injections of LPS may be the result of a release of DNA in a particularly immunogenic form at a time when the immune system, in particular the B lymphocytes, is rendered capable by LPS of developing an immune response to such a soluble antigen. These effects of LPS may account for the triggering or the exacerbation of ante-DNA antibodies during infections with gram-negative bacteria, and a similar mechanism may be involved in the pathogenesis of systemic lupus erythematosus.

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“…2) A N F induced infection: ANF has also been found in experimental animals following infection with Gram-negative bacteria (Christian et al 1965, Grabar et al 1968), virus (Cannat & Varet 1972, Dixon et al 1974, Allison 1977, or parasites (Lambert & Houba 1974). Conceivably infection of the recipients during the course of the immunization might account for the appearance of ANF.…”

Section: Discussionmentioning

confidence: 99%

Antinuclear factors in murine alloantisera

1981

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We have demonstrated that anti-Thy 1.1 and certain of H-2 alloantisera contain an antinuclear factor (ANF) detected by fluorescent antimouse IgG. The incidence of ANF positive antisera that we report may actually be an underestimate. ANF is present in sera not only from our laboratory but also from other sources; thus ANF is not an artifact of our laboratory. ANF is not identical to alloantibody, and the ANF appears to be of an autoimmune nature. A variety of environmental and genetic factors may influence the appearance of ANF in anti-H-2 sera, but we believe that the consistent detection of ANF in sera directed against H-2.31,34 or against H-2.4 suggest that some specific aspect of immune stimulation by these H-2 antigens, and likely by other H-2 antigenic specifications, induces the appearance of ANF. It is not known whether it is these K and D antigens or other determinants associated with the H-2 complex that may actually provide the immune stimulation for ANF induction. The particular mechanisms that may be operating to induce ANF cannot be determined at present. We are continuing with experiments to define what parameters influence the appearance of ANF in alloantisera.

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Formation and Isolation of Antibodies Specific for Nucleotides

Cited by 6 publications

References 10 publications

Immunological Tolerance Affects Only a Subpopulation of the Antigen‐Specific B Lymphocytes: Evidence against Clonal Deletion as the Mechanism of Tolerance Induction

Immunological Tolerance Affects Only a Subpopulation of the Antigen‐Specific B Lymphocytes: Evidence against Clonal Deletion as the Mechanism of Tolerance Induction

Release of Dna in Circulating Blood and Induction of Anti-Dna Antibodies After Injection of Bacterial Lipopolysaccharides

Antinuclear factors in murine alloantisera

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